Resveratrol Prevention of Diabetic Nephropathy is Associated with the Suppression of Renal Inflammation and Mesangial Cell Proliferation: Possible Roles of AktNF- κ B Pathway
Joint Authors
Yuan, Hang
Sun, Jing
Cui, Wen-peng
Xu, Feng
Wang, Yuehui
Wu, Man
Guo, Qiaoyan
Kong, Lili
Wu, Hao
Miao, Lining
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The present study was to investigate the protection of resveratrol (RSV) in diabetes associated with kidney inflammation and cell proliferation.
Rat mesangial cell and streptozotocin-induced type 1 diabetes mouse model were used.
In vitro, RSV attenuated high glucose-induced plasminogen activator inhibitor (PAI-1) expression and mesangial cell proliferation, as well as Akt and nuclear factor-kappa B (NF-κB) activation.
The similar results were recaptured in the experiment with Akt inhibitors.
In vivo, mice were divided into three groups: control group, diabetes mellitus (DM) group, and RSV-treated DM group.
Compared with control group, the kidney weight to body weight ratio and albumin to creatinine ratio were increased in DM group, but not in RSV-treated DM group.
Furthermore, the increased expression of PAI-1 and intercellular adhesion molecule-1 in diabetic renal cortex were also reduced by RSV administration.
Besides, the kidney p-Akt/Akt ratio and NF-κB were significantly increased in DM group; however, these changes were reversed in RSV-treated DM group.
Additionally, immunohistochemistry results indicated that RSV treatment reduced the density of proliferating cell nuclear antigen-positive cells significantly in glomeruli of diabetic mice.
These results suggest that RSV prevents diabetes-induced renal inflammation and mesangial cell proliferation possibly through Akt/NF-κB pathway inhibition.
American Psychological Association (APA)
Xu, Feng& Wang, Yuehui& Cui, Wen-peng& Yuan, Hang& Sun, Jing& Wu, Man…[et al.]. 2014. Resveratrol Prevention of Diabetic Nephropathy is Associated with the Suppression of Renal Inflammation and Mesangial Cell Proliferation: Possible Roles of AktNF- κ B Pathway. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1036449
Modern Language Association (MLA)
Xu, Feng…[et al.]. Resveratrol Prevention of Diabetic Nephropathy is Associated with the Suppression of Renal Inflammation and Mesangial Cell Proliferation: Possible Roles of AktNF- κ B Pathway. International Journal of Endocrinology No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1036449
American Medical Association (AMA)
Xu, Feng& Wang, Yuehui& Cui, Wen-peng& Yuan, Hang& Sun, Jing& Wu, Man…[et al.]. Resveratrol Prevention of Diabetic Nephropathy is Associated with the Suppression of Renal Inflammation and Mesangial Cell Proliferation: Possible Roles of AktNF- κ B Pathway. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1036449
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036449