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Liraglutide Exerts Antidiabetic Effect via PTP1B and PI3KAkt2 Signaling Pathway in Skeletal Muscle of KKAy Mice
المؤلفون المشاركون
Ji, Wenjun
Chen, Xinlin
Lv, Juan
Wang, Meng
Ren, Shuting
Yuan, Bingxiang
Wang, Bing
Chen, Lina
المصدر
International Journal of Endocrinology
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-11
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Liraglutide (a glucagon-like peptide 1 analog) was used for the treatment of type 2 diabetes (T2DM) which could produce glucose-dependent insulin secretion.
Aim.
The aim was to investigate whether liraglutide could improve myofibril and mitochondria injury in skeletal muscle and the mechanisms in diabetic KKAy mice.
Method.
We divided the male KKAy mice into 2 groups: liraglutide group (250 μg/kg/day liraglutide subcutaneous injection) and model group; meanwhile, the male C57BL/6J mice were considered as the control.
After 6 weeks, the ultrastructure of skeletal muscle was observed by electron microscope.
The gene expressions of protein tyrosine phosphatase 1B (PTP1B), phosphatidylinositol 3-kinase (PI3K), and glucose transporter type 4 (GLUT4) were determined by real-time PCR.
The protein levels of the above molecules and phospho-Akt2 (p-Akt2) were measured by Western blot.
Results.
Liraglutide significantly ameliorated the injury of mitochondria by increasing the number (+441%) and the area (+113%) of mitochondria and mitochondrial area/100 µm2 (+396%) in skeletal muscle of KKAy mice.
The results of real-time PCR and Western blot showed that liraglutide downregulated PTP1B while it upregulated PI3K and GLUT4 (P<0.01).
The protein level of p-Akt2/Akt2 was also increased (P<0.01).
Conclusion.
These results revealed that liraglutide could improve myofibril and mitochondria injury in skeletal muscle against T2DM via PTP1B and PI3K/Akt2 signaling pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ji, Wenjun& Chen, Xinlin& Lv, Juan& Wang, Meng& Ren, Shuting& Yuan, Bingxiang…[et al.]. 2014. Liraglutide Exerts Antidiabetic Effect via PTP1B and PI3KAkt2 Signaling Pathway in Skeletal Muscle of KKAy Mice. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1036461
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ji, Wenjun…[et al.]. Liraglutide Exerts Antidiabetic Effect via PTP1B and PI3KAkt2 Signaling Pathway in Skeletal Muscle of KKAy Mice. International Journal of Endocrinology No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1036461
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ji, Wenjun& Chen, Xinlin& Lv, Juan& Wang, Meng& Ren, Shuting& Yuan, Bingxiang…[et al.]. Liraglutide Exerts Antidiabetic Effect via PTP1B and PI3KAkt2 Signaling Pathway in Skeletal Muscle of KKAy Mice. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1036461
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1036461
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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