Gene Expression Profiling of the Paracrine Effects of Uterine Natural Killer Cells on Human Endometrial Epithelial Cells
المؤلفون المشاركون
Gong, Xin
Chen, Zhenzhen
Liu, Yanxia
Lu, Qiudan
Jin, Zhe
المصدر
International Journal of Endocrinology
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-26
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
The endometrium contains a population of immune cells that undergo changes during implantation and pregnancy.
The majority of these cells are uterine natural killer (uNK) cells; however, it is unclear how these cells interact with endometrial epithelial cells.
Therefore, we investigated the paracrine effects of the uNK cell-secretion medium on the gene expression profile of endometrial epithelial cells in vitro through microarray analysis.
Our results, which were verified by qRT-PCR and western blot, revealed that soluble factors from uNK cells alter the gene expression profiles of epithelial cells.
The upregulated genes included interleukin-15 (IL-15) and interleukin-15 receptor alpha (IL-15RA), which result in a loop that stimulates uNK cell proliferation.
In addition, vascular endothelial growth factor C (VEGF-C) and chemokine (C-X-C motif) ligand 10 (CXCL-10) were also determined to be upregulated in epithelial cells, which suggests that uNK cells work synergistically with epithelial cells to support implantation and pregnancy.
In addition, oriental herbal medicines have been used to treat infertility since ancient times; however, we failed to find that Zi Dan Yin can regulate these endometrial paracrine effects.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gong, Xin& Chen, Zhenzhen& Liu, Yanxia& Lu, Qiudan& Jin, Zhe. 2014. Gene Expression Profiling of the Paracrine Effects of Uterine Natural Killer Cells on Human Endometrial Epithelial Cells. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1036488
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gong, Xin…[et al.]. Gene Expression Profiling of the Paracrine Effects of Uterine Natural Killer Cells on Human Endometrial Epithelial Cells. International Journal of Endocrinology No. 2014 (2014), pp.1-15.
https://search.emarefa.net/detail/BIM-1036488
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gong, Xin& Chen, Zhenzhen& Liu, Yanxia& Lu, Qiudan& Jin, Zhe. Gene Expression Profiling of the Paracrine Effects of Uterine Natural Killer Cells on Human Endometrial Epithelial Cells. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1036488
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1036488
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر