Stress Hyperglycemia, Insulin Treatment, and Innate Immune Cells
المؤلفون المشاركون
Xiu, Fangming
Stanojcic, Mile
Diao, Li
Jeschke, Marc G.
المصدر
International Journal of Endocrinology
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-08
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Hyperglycemia (HG) and insulin resistance are the hallmarks of a profoundly altered metabolism in critical illness resulting from the release of cortisol, catecholamines, and cytokines, as well as glucagon and growth hormone.
Recent studies have proposed a fundamental role of the immune system towards the development of insulin resistance in traumatic patients.
A comprehensive review of published literatures on the effects of hyperglycemia and insulin on innate immunity in critical illness was conducted.
This review explored the interaction between the innate immune system and trauma-induced hypermetabolism, while providing greater insight into unraveling the relationship between innate immune cells and hyperglycemia.
Critical illness substantially disturbs glucose metabolism resulting in a state of hyperglycemia.
Alterations in glucose and insulin regulation affect the immune function of cellular components comprising the innate immunity system.
Innate immune system dysfunction via hyperglycemia is associated with a higher morbidity and mortality in critical illness.
Along with others, we hypothesize that reduction in morbidity and mortality observed in patients receiving insulin treatment is partially due to its effect on the attenuation of the immune response.
However, there still remains substantial controversy regarding moderate versus intensive insulin treatment.
Future studies need to determine the integrated effects of HG and insulin on the regulation of innate immunity in order to provide more effective insulin treatment regimen for these patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xiu, Fangming& Stanojcic, Mile& Diao, Li& Jeschke, Marc G.. 2014. Stress Hyperglycemia, Insulin Treatment, and Innate Immune Cells. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1036502
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xiu, Fangming…[et al.]. Stress Hyperglycemia, Insulin Treatment, and Innate Immune Cells. International Journal of Endocrinology No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1036502
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xiu, Fangming& Stanojcic, Mile& Diao, Li& Jeschke, Marc G.. Stress Hyperglycemia, Insulin Treatment, and Innate Immune Cells. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1036502
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1036502
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر