Stress Hyperglycemia, Insulin Treatment, and Innate Immune Cells
Joint Authors
Xiu, Fangming
Stanojcic, Mile
Diao, Li
Jeschke, Marc G.
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Hyperglycemia (HG) and insulin resistance are the hallmarks of a profoundly altered metabolism in critical illness resulting from the release of cortisol, catecholamines, and cytokines, as well as glucagon and growth hormone.
Recent studies have proposed a fundamental role of the immune system towards the development of insulin resistance in traumatic patients.
A comprehensive review of published literatures on the effects of hyperglycemia and insulin on innate immunity in critical illness was conducted.
This review explored the interaction between the innate immune system and trauma-induced hypermetabolism, while providing greater insight into unraveling the relationship between innate immune cells and hyperglycemia.
Critical illness substantially disturbs glucose metabolism resulting in a state of hyperglycemia.
Alterations in glucose and insulin regulation affect the immune function of cellular components comprising the innate immunity system.
Innate immune system dysfunction via hyperglycemia is associated with a higher morbidity and mortality in critical illness.
Along with others, we hypothesize that reduction in morbidity and mortality observed in patients receiving insulin treatment is partially due to its effect on the attenuation of the immune response.
However, there still remains substantial controversy regarding moderate versus intensive insulin treatment.
Future studies need to determine the integrated effects of HG and insulin on the regulation of innate immunity in order to provide more effective insulin treatment regimen for these patients.
American Psychological Association (APA)
Xiu, Fangming& Stanojcic, Mile& Diao, Li& Jeschke, Marc G.. 2014. Stress Hyperglycemia, Insulin Treatment, and Innate Immune Cells. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1036502
Modern Language Association (MLA)
Xiu, Fangming…[et al.]. Stress Hyperglycemia, Insulin Treatment, and Innate Immune Cells. International Journal of Endocrinology No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1036502
American Medical Association (AMA)
Xiu, Fangming& Stanojcic, Mile& Diao, Li& Jeschke, Marc G.. Stress Hyperglycemia, Insulin Treatment, and Innate Immune Cells. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1036502
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036502