Mitochondrial DNA Copy Number in Peripheral Blood Is Independently Associated with Visceral Fat Accumulation in Healthy Young Adults
المؤلفون المشاركون
Im, Jee Ae
Lee, Jee-Yon
Lee, Duk-Chul
Lee, Ji-Won
المصدر
International Journal of Endocrinology
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-24
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Aims.
Visceral obesity is associated with an increased risk of cardiometabolic diseases and it is important to identify the underlying mechanisms.
There is growing evidence that mitochondrial dysfunction is associated with metabolic disturbances related to visceral obesity.
In addition, maintaining mitochondrial DNA (mtDNA) copy number is important for preserving mitochondrial function.
Therefore, we investigated the relationship between mtDNA copy number and visceral fat in healthy young adults.
Methods.
A total of 94 healthy young subjects were studied.
Biomarkers of metabolic risk factors were assessed along with body composition by computed tomography.
mtDNA copy number was measured in peripheral leukocytes using real-time polymerase chain reaction (PCR) methods.
Results.
The mtDNA copy number correlated with BMI ( r = - 0.22 , P = 0.04 ), waist circumference ( r = - 0.23 , P = 0.03 ), visceral fat area ( r = - 0.28 , P = -0.01 ), HDL-cholesterol levels ( r = 0.25 , P = 0.02 ), and hs-CRP ( r = 0.32 , P = 0.02 ) after adjusting for age and sex.
Both stepwise and nonstepwise multiple regression analyses confirmed that visceral fat area was independently associated with mtDNA copy number ( β = -0.33 , P < 0.01 , β = 0.32 , and P = 0.03 , resp.).
Conclusions.
An independent association between mtDNA content and visceral adiposity was identified.
These data suggest that mtDNA copy number is a potential predictive marker for metabolic disturbances.
Further studies are required to understand the causality and clinical significance of our findings.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lee, Jee-Yon& Lee, Duk-Chul& Im, Jee Ae& Lee, Ji-Won. 2014. Mitochondrial DNA Copy Number in Peripheral Blood Is Independently Associated with Visceral Fat Accumulation in Healthy Young Adults. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1036527
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lee, Jee-Yon…[et al.]. Mitochondrial DNA Copy Number in Peripheral Blood Is Independently Associated with Visceral Fat Accumulation in Healthy Young Adults. International Journal of Endocrinology No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1036527
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lee, Jee-Yon& Lee, Duk-Chul& Im, Jee Ae& Lee, Ji-Won. Mitochondrial DNA Copy Number in Peripheral Blood Is Independently Associated with Visceral Fat Accumulation in Healthy Young Adults. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1036527
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1036527
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر