Mitochondrial DNA Copy Number in Peripheral Blood Is Independently Associated with Visceral Fat Accumulation in Healthy Young Adults
Joint Authors
Im, Jee Ae
Lee, Jee-Yon
Lee, Duk-Chul
Lee, Ji-Won
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-24
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aims.
Visceral obesity is associated with an increased risk of cardiometabolic diseases and it is important to identify the underlying mechanisms.
There is growing evidence that mitochondrial dysfunction is associated with metabolic disturbances related to visceral obesity.
In addition, maintaining mitochondrial DNA (mtDNA) copy number is important for preserving mitochondrial function.
Therefore, we investigated the relationship between mtDNA copy number and visceral fat in healthy young adults.
Methods.
A total of 94 healthy young subjects were studied.
Biomarkers of metabolic risk factors were assessed along with body composition by computed tomography.
mtDNA copy number was measured in peripheral leukocytes using real-time polymerase chain reaction (PCR) methods.
Results.
The mtDNA copy number correlated with BMI ( r = - 0.22 , P = 0.04 ), waist circumference ( r = - 0.23 , P = 0.03 ), visceral fat area ( r = - 0.28 , P = -0.01 ), HDL-cholesterol levels ( r = 0.25 , P = 0.02 ), and hs-CRP ( r = 0.32 , P = 0.02 ) after adjusting for age and sex.
Both stepwise and nonstepwise multiple regression analyses confirmed that visceral fat area was independently associated with mtDNA copy number ( β = -0.33 , P < 0.01 , β = 0.32 , and P = 0.03 , resp.).
Conclusions.
An independent association between mtDNA content and visceral adiposity was identified.
These data suggest that mtDNA copy number is a potential predictive marker for metabolic disturbances.
Further studies are required to understand the causality and clinical significance of our findings.
American Psychological Association (APA)
Lee, Jee-Yon& Lee, Duk-Chul& Im, Jee Ae& Lee, Ji-Won. 2014. Mitochondrial DNA Copy Number in Peripheral Blood Is Independently Associated with Visceral Fat Accumulation in Healthy Young Adults. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1036527
Modern Language Association (MLA)
Lee, Jee-Yon…[et al.]. Mitochondrial DNA Copy Number in Peripheral Blood Is Independently Associated with Visceral Fat Accumulation in Healthy Young Adults. International Journal of Endocrinology No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1036527
American Medical Association (AMA)
Lee, Jee-Yon& Lee, Duk-Chul& Im, Jee Ae& Lee, Ji-Won. Mitochondrial DNA Copy Number in Peripheral Blood Is Independently Associated with Visceral Fat Accumulation in Healthy Young Adults. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1036527
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036527