Investigation of the Protective Effects of Taurine against Alloxan-Induced Diabetic Retinal Changes via Electroretinogram and Retinal Histology with New Zealand White Rabbits
المؤلفون المشاركون
Chiang, Samuel Tung-Hsing
Yeh, Shang-Min
Chen, Yi-Chen
Lin, Shiun-Long
Tseng, Jung-Kai
المصدر
International Journal of Endocrinology
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-09-14
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The purpose of this study was to investigate the protective role of orally administered taurine against diabetic retinal changes via electroretinogram (ERG) and retinal histology on rabbits.
Rabbits were randomly assigned into groups: Group I (vehicle administration only); Group II (diabetes: induced by 100 mg/kg alloxan injection); Group III (diabetes and fed with 200 mg/kg taurine); and Group IV (diabetes and fed with 400 mg/kg taurine).
The body weight and blood glucose levels of the rabbits were monitored weekly.
The ERG was measured on weeks 5 and 15.
Retinal histology was analyzed in the end of the experiment.
Results revealed that a taurine supplement significantly ameliorates the alloxan-induced hyperglycemia and protects the retina from electrophysiological changes.
Group II showed a significant (P<0.05) change in the mean scotopic b-wave amplitude when compared to that of Group I, whereas the diabetic rabbits treated with taurine (Group III and IV) were analogous to Group I.
Histologically, the amount of Bipolar and Müller cells showed no difference (P>0.05) between all groups and when compared with those of Group I.
Our study provides solid evidences that taurine possesses an antidiabetic activity, reduced loss of body weight, and less electrophysiological changes of the diabetic retina.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chiang, Samuel Tung-Hsing& Yeh, Shang-Min& Chen, Yi-Chen& Lin, Shiun-Long& Tseng, Jung-Kai. 2014. Investigation of the Protective Effects of Taurine against Alloxan-Induced Diabetic Retinal Changes via Electroretinogram and Retinal Histology with New Zealand White Rabbits. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1036545
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chiang, Samuel Tung-Hsing…[et al.]. Investigation of the Protective Effects of Taurine against Alloxan-Induced Diabetic Retinal Changes via Electroretinogram and Retinal Histology with New Zealand White Rabbits. International Journal of Endocrinology No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1036545
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chiang, Samuel Tung-Hsing& Yeh, Shang-Min& Chen, Yi-Chen& Lin, Shiun-Long& Tseng, Jung-Kai. Investigation of the Protective Effects of Taurine against Alloxan-Induced Diabetic Retinal Changes via Electroretinogram and Retinal Histology with New Zealand White Rabbits. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1036545
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1036545
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر