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Investigation of the Protective Effects of Taurine against Alloxan-Induced Diabetic Retinal Changes via Electroretinogram and Retinal Histology with New Zealand White Rabbits
Joint Authors
Chiang, Samuel Tung-Hsing
Yeh, Shang-Min
Chen, Yi-Chen
Lin, Shiun-Long
Tseng, Jung-Kai
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The purpose of this study was to investigate the protective role of orally administered taurine against diabetic retinal changes via electroretinogram (ERG) and retinal histology on rabbits.
Rabbits were randomly assigned into groups: Group I (vehicle administration only); Group II (diabetes: induced by 100 mg/kg alloxan injection); Group III (diabetes and fed with 200 mg/kg taurine); and Group IV (diabetes and fed with 400 mg/kg taurine).
The body weight and blood glucose levels of the rabbits were monitored weekly.
The ERG was measured on weeks 5 and 15.
Retinal histology was analyzed in the end of the experiment.
Results revealed that a taurine supplement significantly ameliorates the alloxan-induced hyperglycemia and protects the retina from electrophysiological changes.
Group II showed a significant (P<0.05) change in the mean scotopic b-wave amplitude when compared to that of Group I, whereas the diabetic rabbits treated with taurine (Group III and IV) were analogous to Group I.
Histologically, the amount of Bipolar and Müller cells showed no difference (P>0.05) between all groups and when compared with those of Group I.
Our study provides solid evidences that taurine possesses an antidiabetic activity, reduced loss of body weight, and less electrophysiological changes of the diabetic retina.
American Psychological Association (APA)
Chiang, Samuel Tung-Hsing& Yeh, Shang-Min& Chen, Yi-Chen& Lin, Shiun-Long& Tseng, Jung-Kai. 2014. Investigation of the Protective Effects of Taurine against Alloxan-Induced Diabetic Retinal Changes via Electroretinogram and Retinal Histology with New Zealand White Rabbits. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1036545
Modern Language Association (MLA)
Chiang, Samuel Tung-Hsing…[et al.]. Investigation of the Protective Effects of Taurine against Alloxan-Induced Diabetic Retinal Changes via Electroretinogram and Retinal Histology with New Zealand White Rabbits. International Journal of Endocrinology No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1036545
American Medical Association (AMA)
Chiang, Samuel Tung-Hsing& Yeh, Shang-Min& Chen, Yi-Chen& Lin, Shiun-Long& Tseng, Jung-Kai. Investigation of the Protective Effects of Taurine against Alloxan-Induced Diabetic Retinal Changes via Electroretinogram and Retinal Histology with New Zealand White Rabbits. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1036545
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036545