Emerging Targets in Pituitary Adenomas: Role of the CXCL12CXCR4-R7 System
المؤلفون المشاركون
Thellung, Stefano
Gatto, Federico
Albertelli, Manuela
Ferone, Diego
Würth, Roberto
Barbieri, Federica
Villa, Valentina
Nizzari, Mario
Florio, Tullio
Corsaro, Alessandro
المصدر
International Journal of Endocrinology
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-11-16
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Chemokines are chemotactic regulators of immune surveillance in physiological and pathological conditions such as inflammation, infection, and cancer.
Several chemokines and cognate receptors are constitutively expressed in the central nervous system, not only in glial and endothelial cells but also in neurons, controlling neurogenesis, neurite outgrowth, and axonal guidance during development.
In particular, the chemokine CXCL12 and its receptors, CXCR4 and CXCR7, form a functional network that controls plasticity in different brain areas, influencing neurotransmission, neuromodulation, and cell migration, and the dysregulation of this chemokinergic axis is involved in several neurodegenerative, neuroinflammatory, and malignant diseases.
CXCR4 primarily mediates the transduction of proliferative signals, while CXCR7 seems to be mainly responsible for scavenging CXCL12.
Importantly, the multiple intracellular signalling generated by CXCL12 interaction with its receptors influences hypothalamic modulation of neuroendocrine functions, although a direct modulation of pituitary functioning via autocrine/paracrine mechanisms was also reported.
Both CXCL12 and CXCR4 are constitutively overexpressed in pituitary adenomas and their signalling induces cell survival and proliferation, as well as hormonal hypersecretion.
In this review we focus on the physiological and pathological functions of immune-related cyto- and chemokines, mainly focusing on the CXCL12/CXCR4-7 axis, and their role in pituitary tumorigenesis.
Accordingly, we discuss the potential targeting of CXCR4 as novel pharmacological approach for pituitary adenomas.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Barbieri, Federica& Thellung, Stefano& Würth, Roberto& Gatto, Federico& Corsaro, Alessandro& Villa, Valentina…[et al.]. 2014. Emerging Targets in Pituitary Adenomas: Role of the CXCL12CXCR4-R7 System. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1036581
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Barbieri, Federica…[et al.]. Emerging Targets in Pituitary Adenomas: Role of the CXCL12CXCR4-R7 System. International Journal of Endocrinology No. 2014 (2014), pp.1-16.
https://search.emarefa.net/detail/BIM-1036581
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Barbieri, Federica& Thellung, Stefano& Würth, Roberto& Gatto, Federico& Corsaro, Alessandro& Villa, Valentina…[et al.]. Emerging Targets in Pituitary Adenomas: Role of the CXCL12CXCR4-R7 System. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1036581
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1036581
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر