Emerging Targets in Pituitary Adenomas: Role of the CXCL12CXCR4-R7 System
Joint Authors
Thellung, Stefano
Gatto, Federico
Albertelli, Manuela
Ferone, Diego
Würth, Roberto
Barbieri, Federica
Villa, Valentina
Nizzari, Mario
Florio, Tullio
Corsaro, Alessandro
Source
International Journal of Endocrinology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-16
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Chemokines are chemotactic regulators of immune surveillance in physiological and pathological conditions such as inflammation, infection, and cancer.
Several chemokines and cognate receptors are constitutively expressed in the central nervous system, not only in glial and endothelial cells but also in neurons, controlling neurogenesis, neurite outgrowth, and axonal guidance during development.
In particular, the chemokine CXCL12 and its receptors, CXCR4 and CXCR7, form a functional network that controls plasticity in different brain areas, influencing neurotransmission, neuromodulation, and cell migration, and the dysregulation of this chemokinergic axis is involved in several neurodegenerative, neuroinflammatory, and malignant diseases.
CXCR4 primarily mediates the transduction of proliferative signals, while CXCR7 seems to be mainly responsible for scavenging CXCL12.
Importantly, the multiple intracellular signalling generated by CXCL12 interaction with its receptors influences hypothalamic modulation of neuroendocrine functions, although a direct modulation of pituitary functioning via autocrine/paracrine mechanisms was also reported.
Both CXCL12 and CXCR4 are constitutively overexpressed in pituitary adenomas and their signalling induces cell survival and proliferation, as well as hormonal hypersecretion.
In this review we focus on the physiological and pathological functions of immune-related cyto- and chemokines, mainly focusing on the CXCL12/CXCR4-7 axis, and their role in pituitary tumorigenesis.
Accordingly, we discuss the potential targeting of CXCR4 as novel pharmacological approach for pituitary adenomas.
American Psychological Association (APA)
Barbieri, Federica& Thellung, Stefano& Würth, Roberto& Gatto, Federico& Corsaro, Alessandro& Villa, Valentina…[et al.]. 2014. Emerging Targets in Pituitary Adenomas: Role of the CXCL12CXCR4-R7 System. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1036581
Modern Language Association (MLA)
Barbieri, Federica…[et al.]. Emerging Targets in Pituitary Adenomas: Role of the CXCL12CXCR4-R7 System. International Journal of Endocrinology No. 2014 (2014), pp.1-16.
https://search.emarefa.net/detail/BIM-1036581
American Medical Association (AMA)
Barbieri, Federica& Thellung, Stefano& Würth, Roberto& Gatto, Federico& Corsaro, Alessandro& Villa, Valentina…[et al.]. Emerging Targets in Pituitary Adenomas: Role of the CXCL12CXCR4-R7 System. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1036581
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1036581