Circulating MicroRNAs in Plasma of Hepatitis B e Antigen Positive Children Reveal Liver-Specific Target Genes
المؤلفون المشاركون
Winther, Thilde Nordmann
Jacobsen, Kari Stougaard
Mirza, Aashiq Hussain
Heiberg, Ida Louise
Bang-Berthelsen, Claus Heiner
Pociot, Flemming
Hogh, Birthe
المصدر
International Journal of Hepatology
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-12-17
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background and Aim.
Hepatitis B e antigen positive (HBeAg-positive) children are at high risk of severe complications such as hepatocellular carcinoma and cirrhosis.
Liver damage is caused by the host immune response to infected hepatocytes, and we hypothesise that specific microRNAs play a role in this complex interaction between virus and host.
The study aimed to identify microRNAs with aberrant plasma expressions in HBeAg-positive children and with liver-specific target genes.
Methods.
By revisiting our previous screen of microRNA plasma levels in HBeAg-positive and HBeAg-negative children with chronic hepatitis B (CHB) and in healthy controls, candidate microRNAs with aberrant plasma expressions in HBeAg-positive children were identified.
MicroRNAs targeting liver-specific genes were selected based on bioinformatics analysis and validated by qRT-PCR using plasma samples from 34 HBeAg-positive, 26 HBeAg-negative, and 60 healthy control children.
Results.
Thirteen microRNAs showed aberrant plasma expressions in HBeAg-positive children and targeted liver-specific genes.
In particular, three microRNAs were upregulated and one was downregulated in HBeAg-positive children compared to HBeAg-negative and healthy control children, which showed equal levels.
Conclusion.
The identified microRNAs might impact the progression of CHB in children.
Functional studies are warranted, however, to elucidate the microRNAs’ role in the immunopathogenesis of childhood CHB.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Winther, Thilde Nordmann& Jacobsen, Kari Stougaard& Mirza, Aashiq Hussain& Heiberg, Ida Louise& Bang-Berthelsen, Claus Heiner& Pociot, Flemming…[et al.]. 2014. Circulating MicroRNAs in Plasma of Hepatitis B e Antigen Positive Children Reveal Liver-Specific Target Genes. International Journal of Hepatology،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1036710
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Winther, Thilde Nordmann…[et al.]. Circulating MicroRNAs in Plasma of Hepatitis B e Antigen Positive Children Reveal Liver-Specific Target Genes. International Journal of Hepatology No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1036710
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Winther, Thilde Nordmann& Jacobsen, Kari Stougaard& Mirza, Aashiq Hussain& Heiberg, Ida Louise& Bang-Berthelsen, Claus Heiner& Pociot, Flemming…[et al.]. Circulating MicroRNAs in Plasma of Hepatitis B e Antigen Positive Children Reveal Liver-Specific Target Genes. International Journal of Hepatology. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1036710
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1036710
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر