Neuroprotective Activity of Water Soluble Extract from Chorispora bungeana against Focal Cerebral IschemicReperfusion Injury in Mice

الملخص EN

The purpose of the present study was to clarify whether the water extract of Chorispora bungeana was an antioxidant agent against cerebral ischemia/reperfusion (I/R).

Our results showed that water extract of Chorispora bungeana treatment significantly reduced neurological deficit scores, infarct size, MDA and carbonyl contents, and GSH/GSSG ratio compared with the model control group.

After being treated by Chorispora bungeana, SOD, CAT, and GSH-Px activities remarkably increased.

Chorispora bungeana treatment also improved 8-OHdG expression and cell apoptosis.

Our findings indicated that the water extract of Chorispora bungeana possesses neuroprotective effect which is most likely achieved by antioxidant and antiapoptotic activities.