Synthesis, Single Crystal X-Ray Structure, and Antimicrobial Activity of 6-(1,3-Benzodioxol-5-ylmethyl)‎-5-ethyl-2-{[2-(morpholin-4-yl)‎ethyl]sulfanyl}pyrimidin-4(3H)‎-one

الملخص EN

Synthesis, X-ray structure and antimicrobial activity of 6-(1,3-benzodioxol-5-ylmethyl)-5-ethyl-2-{[2-(morpholin-4-yl)ethyl]sulfanyl}pyrimidin-4(3H)-one (8) are reported.

Compound 8 exhibited activity towards S.

aureus with MIC value of 0.0619 μmol/mL while it showed activity towards B.

subtilis, B.

cereus, C.

albicans, and A.

niger with MIC = 0.1859 μmol/mL.

Single crystal X-ray structure of the title compound 8 confirmed its S-alkylation.

The title compound crystallizes in the triclinic, P -1, a = 11.1220 (5) Å, b = 12.2241 (5) Å, c = 21.5246 (9) Å, α = 88.958 (2)°, β = 79.836 (2)°, γ = 79.384 (2)°, V = 2830.9 (2) Å3, Z = 6 , R ( F ) = 0.046 , w R ( F 2 ) = 0.110 , T = 100 K.

The crystal structure is stabilized by weak intermolecular C–H ⋯ O and N–H ⋯ O hydrogen interactions.