Ethanol at Low Concentration Attenuates Diabetes Induced Lung Injury in Rats Model
المؤلفون المشاركون
Hu, Jun-Feng
Zhang, Guan-Jun
Wang, Lei
Kang, Pin-Fang
Li, Jun
Wang, Hong-Ju
Gao, Qin
Chen, Yu-Qing
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-12
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
To observe the changes of lung injury when diabetic rats were treated with low concentration of ethanol (EtOH) and analyze the related mechanisms, male Sprague-Dawley (SD) rats were divided into control, diabetic (DM), and EtOH+DM groups.
Diabetic rat was mimicked by injection of streptozotocin intraperitoneally.
Fasting blood glucose (FBG) level, lung weight (LW), body weight (BW), and LW/BW were measured.
The changes of lung tissue and Type II alveolar cell were detected.
Pulmonary malondialdehyde (MDA) content and superoxide dismutase (SOD) activity were measured; meanwhile, ALDH2 mRNA and protein expressions were detected by RT-PCR and western blotting, respectively.
Compared with control group, in DM group, SOD activity was decreased; FBG level, LW/BW, MDA content, ALDH2 mRNA, and protein expressions were decreased.
Compared with DM group, in EtOH+DM group, SOD activity, ALDH2 mRNA, and protein expressions were increased; LW/BW and MDA content were decreased.
The structures of lung tissue and lamellar bodies were collapsed in DM group; the injury was attenuated in EtOH+DM group.
Our findings suggested that, in diabetic rat, pulmonary ALDH2 expression was decreased accompanying lung injury.
EtOH at low concentration decreased diabetes induced lung injury through activating ALDH2 expression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hu, Jun-Feng& Zhang, Guan-Jun& Wang, Lei& Kang, Pin-Fang& Li, Jun& Wang, Hong-Ju…[et al.]. 2014. Ethanol at Low Concentration Attenuates Diabetes Induced Lung Injury in Rats Model. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1040221
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hu, Jun-Feng…[et al.]. Ethanol at Low Concentration Attenuates Diabetes Induced Lung Injury in Rats Model. Journal of Diabetes Research No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1040221
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hu, Jun-Feng& Zhang, Guan-Jun& Wang, Lei& Kang, Pin-Fang& Li, Jun& Wang, Hong-Ju…[et al.]. Ethanol at Low Concentration Attenuates Diabetes Induced Lung Injury in Rats Model. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1040221
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1040221
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر