Ethanol at Low Concentration Attenuates Diabetes Induced Lung Injury in Rats Model
Joint Authors
Hu, Jun-Feng
Zhang, Guan-Jun
Wang, Lei
Kang, Pin-Fang
Li, Jun
Wang, Hong-Ju
Gao, Qin
Chen, Yu-Qing
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
To observe the changes of lung injury when diabetic rats were treated with low concentration of ethanol (EtOH) and analyze the related mechanisms, male Sprague-Dawley (SD) rats were divided into control, diabetic (DM), and EtOH+DM groups.
Diabetic rat was mimicked by injection of streptozotocin intraperitoneally.
Fasting blood glucose (FBG) level, lung weight (LW), body weight (BW), and LW/BW were measured.
The changes of lung tissue and Type II alveolar cell were detected.
Pulmonary malondialdehyde (MDA) content and superoxide dismutase (SOD) activity were measured; meanwhile, ALDH2 mRNA and protein expressions were detected by RT-PCR and western blotting, respectively.
Compared with control group, in DM group, SOD activity was decreased; FBG level, LW/BW, MDA content, ALDH2 mRNA, and protein expressions were decreased.
Compared with DM group, in EtOH+DM group, SOD activity, ALDH2 mRNA, and protein expressions were increased; LW/BW and MDA content were decreased.
The structures of lung tissue and lamellar bodies were collapsed in DM group; the injury was attenuated in EtOH+DM group.
Our findings suggested that, in diabetic rat, pulmonary ALDH2 expression was decreased accompanying lung injury.
EtOH at low concentration decreased diabetes induced lung injury through activating ALDH2 expression.
American Psychological Association (APA)
Hu, Jun-Feng& Zhang, Guan-Jun& Wang, Lei& Kang, Pin-Fang& Li, Jun& Wang, Hong-Ju…[et al.]. 2014. Ethanol at Low Concentration Attenuates Diabetes Induced Lung Injury in Rats Model. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1040221
Modern Language Association (MLA)
Hu, Jun-Feng…[et al.]. Ethanol at Low Concentration Attenuates Diabetes Induced Lung Injury in Rats Model. Journal of Diabetes Research No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1040221
American Medical Association (AMA)
Hu, Jun-Feng& Zhang, Guan-Jun& Wang, Lei& Kang, Pin-Fang& Li, Jun& Wang, Hong-Ju…[et al.]. Ethanol at Low Concentration Attenuates Diabetes Induced Lung Injury in Rats Model. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1040221
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040221