Low Protein Diet Inhibits Uric Acid Synthesis and Attenuates Renal Damage in Streptozotocin-Induced Diabetic Rats
المؤلفون المشاركون
Ran, Jianmin
Ma, Jing
Liu, Yan
Tan, Rongshao
Liu, Houqiang
Lao, Gancheng
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-13
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Aim.
Several studies indicated that hyperuricemia may link to the worsening of diabetic nephropathy (DN).
Meanwhile, low protein diet (LPD) retards exacerbation of renal damage in chronic kidney disease.
We then assessed whether LPD influences uric acid metabolism and benefits the progression of DN in streptozotocin- (STZ-) induced diabetic rats.
Methods.
STZ-induced and control rats were both fed with LPD (5%) and normal protein diet (18%), respectively, for 12 weeks.
Vital signs, blood and urinary samples for UA metabolism were taken and analyzed every 3 weeks.
Kidneys were removed at the end of the experiment.
Results.
Diabetic rats developed into constantly high levels of serum UA (SUA), creatinine (SCr) and 24 h amounts of urinary albumin excretion (UAE), creatintine (UCr), urea nitrogen (UUN), and uric acid (UUA).
LPD significantly decreased SUA, UAE, and blood glucose, yet left SCr, UCr, and UUN unchanged.
A stepwise regression showed that high UUA is an independent risk factor for DN.
LPD remarkably ameliorated degrees of enlarged glomeruli, proliferated mesangial cells, and hyaline-degenerated tubular epithelial cells in diabetic rats.
Expression of TNF-α in tubulointerstitium significantly decreased in LPD-fed diabetic rats.
Conclusion.
LPD inhibits endogenous uric acid synthesis and might accordingly attenuate renal damage in STZ-induced diabetic rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ran, Jianmin& Ma, Jing& Liu, Yan& Tan, Rongshao& Liu, Houqiang& Lao, Gancheng. 2014. Low Protein Diet Inhibits Uric Acid Synthesis and Attenuates Renal Damage in Streptozotocin-Induced Diabetic Rats. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1040281
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ran, Jianmin…[et al.]. Low Protein Diet Inhibits Uric Acid Synthesis and Attenuates Renal Damage in Streptozotocin-Induced Diabetic Rats. Journal of Diabetes Research No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1040281
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ran, Jianmin& Ma, Jing& Liu, Yan& Tan, Rongshao& Liu, Houqiang& Lao, Gancheng. Low Protein Diet Inhibits Uric Acid Synthesis and Attenuates Renal Damage in Streptozotocin-Induced Diabetic Rats. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1040281
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1040281
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر