Low Protein Diet Inhibits Uric Acid Synthesis and Attenuates Renal Damage in Streptozotocin-Induced Diabetic Rats
Joint Authors
Ran, Jianmin
Ma, Jing
Liu, Yan
Tan, Rongshao
Liu, Houqiang
Lao, Gancheng
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Aim.
Several studies indicated that hyperuricemia may link to the worsening of diabetic nephropathy (DN).
Meanwhile, low protein diet (LPD) retards exacerbation of renal damage in chronic kidney disease.
We then assessed whether LPD influences uric acid metabolism and benefits the progression of DN in streptozotocin- (STZ-) induced diabetic rats.
Methods.
STZ-induced and control rats were both fed with LPD (5%) and normal protein diet (18%), respectively, for 12 weeks.
Vital signs, blood and urinary samples for UA metabolism were taken and analyzed every 3 weeks.
Kidneys were removed at the end of the experiment.
Results.
Diabetic rats developed into constantly high levels of serum UA (SUA), creatinine (SCr) and 24 h amounts of urinary albumin excretion (UAE), creatintine (UCr), urea nitrogen (UUN), and uric acid (UUA).
LPD significantly decreased SUA, UAE, and blood glucose, yet left SCr, UCr, and UUN unchanged.
A stepwise regression showed that high UUA is an independent risk factor for DN.
LPD remarkably ameliorated degrees of enlarged glomeruli, proliferated mesangial cells, and hyaline-degenerated tubular epithelial cells in diabetic rats.
Expression of TNF-α in tubulointerstitium significantly decreased in LPD-fed diabetic rats.
Conclusion.
LPD inhibits endogenous uric acid synthesis and might accordingly attenuate renal damage in STZ-induced diabetic rats.
American Psychological Association (APA)
Ran, Jianmin& Ma, Jing& Liu, Yan& Tan, Rongshao& Liu, Houqiang& Lao, Gancheng. 2014. Low Protein Diet Inhibits Uric Acid Synthesis and Attenuates Renal Damage in Streptozotocin-Induced Diabetic Rats. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1040281
Modern Language Association (MLA)
Ran, Jianmin…[et al.]. Low Protein Diet Inhibits Uric Acid Synthesis and Attenuates Renal Damage in Streptozotocin-Induced Diabetic Rats. Journal of Diabetes Research No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1040281
American Medical Association (AMA)
Ran, Jianmin& Ma, Jing& Liu, Yan& Tan, Rongshao& Liu, Houqiang& Lao, Gancheng. Low Protein Diet Inhibits Uric Acid Synthesis and Attenuates Renal Damage in Streptozotocin-Induced Diabetic Rats. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1040281
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040281