Effects of Unilateral Nephrectomy on Renal Function in Male Spontaneously Diabetic Torii Fatty Rats: A Novel Obese Type 2 Diabetic Model

الملخص EN

The Spontaneously Diabetic Torii (SDT) fatty rat is a new model for obese type 2 diabetes.

The aim of the present study was to investigate the effect of 1/2 nephrectomy (Nx) on renal function and morphology and on blood pressure in SDT fatty rats.

Male SDT fatty rats underwent 1/2 Nx or a sham operation (Sham).

Subsequently, animals were studied with respect to renal function and histological alterations.

Induction of 1/2 Nx in SDT fatty rats led to functional and morphological damage to the remnant kidney and to hypertension, which are considered main characteristics of chronic kidney disease, at a younger age compared with the sham group.

In conclusion, the SDT fatty rat is useful in investigations to elucidate the pathogenesis of human diabetic nephropathy and in new drug discovery.