Effects of Unilateral Nephrectomy on Renal Function in Male Spontaneously Diabetic Torii Fatty Rats: A Novel Obese Type 2 Diabetic Model
Joint Authors
Maki, Mimi
Katsuda, Yoshiaki
Sano, Ryuhei
Toriniwa, Yasufumi
Kakimoto, Kochi
Ishii, Yukihito
Ohta, Takeshi
Kemmochi, Yusuke
Miyajima, Katsuhiro
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The Spontaneously Diabetic Torii (SDT) fatty rat is a new model for obese type 2 diabetes.
The aim of the present study was to investigate the effect of 1/2 nephrectomy (Nx) on renal function and morphology and on blood pressure in SDT fatty rats.
Male SDT fatty rats underwent 1/2 Nx or a sham operation (Sham).
Subsequently, animals were studied with respect to renal function and histological alterations.
Induction of 1/2 Nx in SDT fatty rats led to functional and morphological damage to the remnant kidney and to hypertension, which are considered main characteristics of chronic kidney disease, at a younger age compared with the sham group.
In conclusion, the SDT fatty rat is useful in investigations to elucidate the pathogenesis of human diabetic nephropathy and in new drug discovery.
American Psychological Association (APA)
Katsuda, Yoshiaki& Kemmochi, Yusuke& Maki, Mimi& Sano, Ryuhei& Toriniwa, Yasufumi& Ishii, Yukihito…[et al.]. 2014. Effects of Unilateral Nephrectomy on Renal Function in Male Spontaneously Diabetic Torii Fatty Rats: A Novel Obese Type 2 Diabetic Model. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1040289
Modern Language Association (MLA)
Katsuda, Yoshiaki…[et al.]. Effects of Unilateral Nephrectomy on Renal Function in Male Spontaneously Diabetic Torii Fatty Rats: A Novel Obese Type 2 Diabetic Model. Journal of Diabetes Research No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1040289
American Medical Association (AMA)
Katsuda, Yoshiaki& Kemmochi, Yusuke& Maki, Mimi& Sano, Ryuhei& Toriniwa, Yasufumi& Ishii, Yukihito…[et al.]. Effects of Unilateral Nephrectomy on Renal Function in Male Spontaneously Diabetic Torii Fatty Rats: A Novel Obese Type 2 Diabetic Model. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1040289
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040289
