Low Molecular Weight Fucoidan Alleviates Cardiac Dysfunction in Diabetic Goto-Kakizaki Rats by Reducing Oxidative Stress and Cardiomyocyte Apoptosis
المؤلفون المشاركون
Wang, Xiao-Min
Yu, Xinfeng
Zhang, Quanbin
Cui, Wentong
Zeng, Zheng
Yang, Wenzhe
Zhang, Chao
Zhao, Hongwei
Gao, Weidong
Luo, Dali
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-11-30
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Diabetic cardiomyopathy (DCM) is characterized by cardiac dysfunction and cardiomyocyte apoptosis.
Oxidative stress is suggested to be the major contributor to the development of DCM.
This study was intended to evaluate the protective effect of low molecular weight fucoidan (LMWF) against cardiac dysfunction in diabetic rats.
Type 2 diabetic goto-kakizaki rats were untreated or treated with LMWF (50 and 100 mg/kg/day) for three months.
The establishment of DCM model and the effects of LMWF on cardiac function were evaluated by echocardiography and isolated heart perfusion.
Ventricle staining with H-E or Sirius Red was performed to investigate the structural changes in myocardium.
Functional evaluation demonstrated that LMWF has a beneficial effect on DCM by enhancing myocardial contractility and mitigating cardiac fibrosis.
Additionally, LMWF exerted significant inhibitory effects on the reactive oxygen species production and myocyte apoptosis in diabetic hearts.
The depressed activity of superoxide dismutase in diabetic heart was also improved by intervention with LMWF.
Moreover, LMWF robustly inhibited the enhanced expression of protein kinase C β, an important contributor to oxidative stress, in diabetic heart and high glucose-treated cardiomyocytes.
In conclusion, LMWF possesses a protective effect against DCM through ameliorations of PKCβ-mediated oxidative stress and subsequent cardiomyocyte apoptosis in diabetes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yu, Xinfeng& Zhang, Quanbin& Cui, Wentong& Zeng, Zheng& Yang, Wenzhe& Zhang, Chao…[et al.]. 2014. Low Molecular Weight Fucoidan Alleviates Cardiac Dysfunction in Diabetic Goto-Kakizaki Rats by Reducing Oxidative Stress and Cardiomyocyte Apoptosis. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1040298
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yu, Xinfeng…[et al.]. Low Molecular Weight Fucoidan Alleviates Cardiac Dysfunction in Diabetic Goto-Kakizaki Rats by Reducing Oxidative Stress and Cardiomyocyte Apoptosis. Journal of Diabetes Research No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1040298
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yu, Xinfeng& Zhang, Quanbin& Cui, Wentong& Zeng, Zheng& Yang, Wenzhe& Zhang, Chao…[et al.]. Low Molecular Weight Fucoidan Alleviates Cardiac Dysfunction in Diabetic Goto-Kakizaki Rats by Reducing Oxidative Stress and Cardiomyocyte Apoptosis. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1040298
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1040298
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر