Low Molecular Weight Fucoidan Alleviates Cardiac Dysfunction in Diabetic Goto-Kakizaki Rats by Reducing Oxidative Stress and Cardiomyocyte Apoptosis
Joint Authors
Wang, Xiao-Min
Yu, Xinfeng
Zhang, Quanbin
Cui, Wentong
Zeng, Zheng
Yang, Wenzhe
Zhang, Chao
Zhao, Hongwei
Gao, Weidong
Luo, Dali
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-30
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Diabetic cardiomyopathy (DCM) is characterized by cardiac dysfunction and cardiomyocyte apoptosis.
Oxidative stress is suggested to be the major contributor to the development of DCM.
This study was intended to evaluate the protective effect of low molecular weight fucoidan (LMWF) against cardiac dysfunction in diabetic rats.
Type 2 diabetic goto-kakizaki rats were untreated or treated with LMWF (50 and 100 mg/kg/day) for three months.
The establishment of DCM model and the effects of LMWF on cardiac function were evaluated by echocardiography and isolated heart perfusion.
Ventricle staining with H-E or Sirius Red was performed to investigate the structural changes in myocardium.
Functional evaluation demonstrated that LMWF has a beneficial effect on DCM by enhancing myocardial contractility and mitigating cardiac fibrosis.
Additionally, LMWF exerted significant inhibitory effects on the reactive oxygen species production and myocyte apoptosis in diabetic hearts.
The depressed activity of superoxide dismutase in diabetic heart was also improved by intervention with LMWF.
Moreover, LMWF robustly inhibited the enhanced expression of protein kinase C β, an important contributor to oxidative stress, in diabetic heart and high glucose-treated cardiomyocytes.
In conclusion, LMWF possesses a protective effect against DCM through ameliorations of PKCβ-mediated oxidative stress and subsequent cardiomyocyte apoptosis in diabetes.
American Psychological Association (APA)
Yu, Xinfeng& Zhang, Quanbin& Cui, Wentong& Zeng, Zheng& Yang, Wenzhe& Zhang, Chao…[et al.]. 2014. Low Molecular Weight Fucoidan Alleviates Cardiac Dysfunction in Diabetic Goto-Kakizaki Rats by Reducing Oxidative Stress and Cardiomyocyte Apoptosis. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1040298
Modern Language Association (MLA)
Yu, Xinfeng…[et al.]. Low Molecular Weight Fucoidan Alleviates Cardiac Dysfunction in Diabetic Goto-Kakizaki Rats by Reducing Oxidative Stress and Cardiomyocyte Apoptosis. Journal of Diabetes Research No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1040298
American Medical Association (AMA)
Yu, Xinfeng& Zhang, Quanbin& Cui, Wentong& Zeng, Zheng& Yang, Wenzhe& Zhang, Chao…[et al.]. Low Molecular Weight Fucoidan Alleviates Cardiac Dysfunction in Diabetic Goto-Kakizaki Rats by Reducing Oxidative Stress and Cardiomyocyte Apoptosis. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1040298
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040298