Effects of Fenofibrate on Adiponectin Expression in Retinas of Streptozotocin-Induced Diabetic Rats
المؤلفون المشاركون
Yang, C.-H.
Hsu, Ying-Jung
Wang, Lu-Chun
Yang, Wei-Shiung
Yang, Chang-Hao
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-12-01
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Adiponectin has been associated with increased risks of microvascular complications in diabetes; however, its role in the development of diabetic retinopathy (DR) is unknown.
Fenofibrate is a lipid-lowering agent that has been shown to be capable of preventing DR progression.
We investigated the expression of adiponectin and its receptors in DR and evaluated the effects of fenofibrate on their expression.
The mRNA and protein levels of adiponectin and its receptors were elevated in retinas of streptozotocin-induced diabetic rats and were suppressed following fenofibrate treatment.
Immunofluorescence staining demonstrated that adiponectin and adipoR1 were expressed in cells located within blood vessels, the retinal ganglion, and the inner nuclear layer.
AdipoR1 was strongly expressed whereas adipoR2 was only weekly expressed in vascular endothelial cells.
The in vitro experiments showed that adiponectin expression was induced by high glucose concentrations in RGC-5 and RAW264.7 cells and was suppressed following fenofibrate treatment.
AdipoR1 and adipoR2 levels in RGC-5 cells were elevated in high glucose concentrations and suppressed by fenofibrate.
Our results demonstrated that adiponectin may be a proinflammatory mediator in diabetic retinas and fenofibrate appears to modulate the expression of adiponectin and its receptors in diabetic retinas, effectively reducing DR progression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hsu, Ying-Jung& Wang, Lu-Chun& Yang, Wei-Shiung& Yang, C.-H.& Yang, Chang-Hao. 2014. Effects of Fenofibrate on Adiponectin Expression in Retinas of Streptozotocin-Induced Diabetic Rats. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1040309
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hsu, Ying-Jung…[et al.]. Effects of Fenofibrate on Adiponectin Expression in Retinas of Streptozotocin-Induced Diabetic Rats. Journal of Diabetes Research No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-1040309
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hsu, Ying-Jung& Wang, Lu-Chun& Yang, Wei-Shiung& Yang, C.-H.& Yang, Chang-Hao. Effects of Fenofibrate on Adiponectin Expression in Retinas of Streptozotocin-Induced Diabetic Rats. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1040309
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1040309
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر