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Effects of Fenofibrate on Adiponectin Expression in Retinas of Streptozotocin-Induced Diabetic Rats
Joint Authors
Yang, C.-H.
Hsu, Ying-Jung
Wang, Lu-Chun
Yang, Wei-Shiung
Yang, Chang-Hao
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-01
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Adiponectin has been associated with increased risks of microvascular complications in diabetes; however, its role in the development of diabetic retinopathy (DR) is unknown.
Fenofibrate is a lipid-lowering agent that has been shown to be capable of preventing DR progression.
We investigated the expression of adiponectin and its receptors in DR and evaluated the effects of fenofibrate on their expression.
The mRNA and protein levels of adiponectin and its receptors were elevated in retinas of streptozotocin-induced diabetic rats and were suppressed following fenofibrate treatment.
Immunofluorescence staining demonstrated that adiponectin and adipoR1 were expressed in cells located within blood vessels, the retinal ganglion, and the inner nuclear layer.
AdipoR1 was strongly expressed whereas adipoR2 was only weekly expressed in vascular endothelial cells.
The in vitro experiments showed that adiponectin expression was induced by high glucose concentrations in RGC-5 and RAW264.7 cells and was suppressed following fenofibrate treatment.
AdipoR1 and adipoR2 levels in RGC-5 cells were elevated in high glucose concentrations and suppressed by fenofibrate.
Our results demonstrated that adiponectin may be a proinflammatory mediator in diabetic retinas and fenofibrate appears to modulate the expression of adiponectin and its receptors in diabetic retinas, effectively reducing DR progression.
American Psychological Association (APA)
Hsu, Ying-Jung& Wang, Lu-Chun& Yang, Wei-Shiung& Yang, C.-H.& Yang, Chang-Hao. 2014. Effects of Fenofibrate on Adiponectin Expression in Retinas of Streptozotocin-Induced Diabetic Rats. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1040309
Modern Language Association (MLA)
Hsu, Ying-Jung…[et al.]. Effects of Fenofibrate on Adiponectin Expression in Retinas of Streptozotocin-Induced Diabetic Rats. Journal of Diabetes Research No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-1040309
American Medical Association (AMA)
Hsu, Ying-Jung& Wang, Lu-Chun& Yang, Wei-Shiung& Yang, C.-H.& Yang, Chang-Hao. Effects of Fenofibrate on Adiponectin Expression in Retinas of Streptozotocin-Induced Diabetic Rats. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1040309
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040309