Generating and Reversing Chronic Wounds in Diabetic Mice by Manipulating Wound Redox Parameters
المؤلفون المشاركون
Martins-Green, Manuela
Dhall, Sandeep
Do, Danh C.
Garcia, Monika
Kim, Jane
Mirebrahim, Seyed H.
Lyubovitsky, Julia
Lonardi, Stefano
Nothnagel, Eugene A.
Schiller, Neal
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-12-23
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
By 2025, more than 500 M people worldwide will suffer from diabetes; 125 M will develop foot ulcer(s) and 20 M will undergo an amputation, creating a major health problem.
Understanding how these wounds become chronic will provide insights to reverse chronicity.
We hypothesized that oxidative stress (OS) in wounds is a critical component for generation of chronicity.
We used the db/db mouse model of impaired healing and inhibited, at time of injury, two major antioxidant enzymes, catalase and glutathione peroxidase, creating high OS in the wounds.
This was necessary and sufficient to trigger wounds to become chronic.
The wounds initially contained a polymicrobial community that with time selected for specific biofilm-forming bacteria.
To reverse chronicity we treated the wounds with the antioxidants α-tocopherol and N-acetylcysteine and found that OS was highly reduced, biofilms had increased sensitivity to antibiotics, and granulation tissue was formed with proper collagen deposition and remodeling.
We show for the first time generation of chronic wounds in which biofilm develops spontaneously, illustrating importance of early and continued redox imbalance coupled with the presence of biofilm in development of wound chronicity.
This model will help decipher additional mechanisms and potentially better diagnosis of chronicity and treatment of human chronic wounds.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dhall, Sandeep& Do, Danh C.& Garcia, Monika& Kim, Jane& Mirebrahim, Seyed H.& Lyubovitsky, Julia…[et al.]. 2014. Generating and Reversing Chronic Wounds in Diabetic Mice by Manipulating Wound Redox Parameters. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-18.
https://search.emarefa.net/detail/BIM-1040311
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dhall, Sandeep…[et al.]. Generating and Reversing Chronic Wounds in Diabetic Mice by Manipulating Wound Redox Parameters. Journal of Diabetes Research No. 2014 (2014), pp.1-18.
https://search.emarefa.net/detail/BIM-1040311
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dhall, Sandeep& Do, Danh C.& Garcia, Monika& Kim, Jane& Mirebrahim, Seyed H.& Lyubovitsky, Julia…[et al.]. Generating and Reversing Chronic Wounds in Diabetic Mice by Manipulating Wound Redox Parameters. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-18.
https://search.emarefa.net/detail/BIM-1040311
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1040311
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر