Histone Lysine Methylation in Diabetic Nephropathy

المؤلفون المشاركون

Cui, Wen-peng
Miao, Lining
Sun, Guang-dong
Guo, Qiao-yan

المصدر

Journal of Diabetes Research

العدد

المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2014-08-25

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

Diabetic nephropathy (DN) belongs to debilitating microvascular complications of diabetes and is the leading cause of end-stage renal diseases worldwide.

Furthermore, outcomes from the DCCT/EDIC study showed that DN often persists and progresses despite intensive glucose control in many diabetes patients, possibly as a result of prior episode of hyperglycemia, which is called “metabolic memory.” The underlying mechanisms responsible for the development and progression of DN remain poorly understood.

Activation of multiple signaling pathways and key transcription factors can lead to aberrant expression of DN-related pathologic genes in target renal cells.

Increasing evidence suggests that epigenetic mechanisms in chromatin such as DNA methylation, histone acetylation, and methylation can influence the pathophysiology of DN and metabolic memory.

Exciting researches from cell culture and experimental animals have shown that key histone methylation patterns and the related histone methyltransferases and histone demethylases can play important roles in the regulation of inflammatory and profibrotic genes in renal cells under diabetic conditions.

Because histone methylation is dynamic and potentially reversible, it can provide a window of opportunity for the development of much-needed novel therapeutic potential for DN in the future.

In this minireview, we discuss recent advances in the field of histone methylation and its roles in the pathogenesis and progression of DN.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Sun, Guang-dong& Cui, Wen-peng& Guo, Qiao-yan& Miao, Lining. 2014. Histone Lysine Methylation in Diabetic Nephropathy. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1040322

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Sun, Guang-dong…[et al.]. Histone Lysine Methylation in Diabetic Nephropathy. Journal of Diabetes Research No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1040322

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Sun, Guang-dong& Cui, Wen-peng& Guo, Qiao-yan& Miao, Lining. Histone Lysine Methylation in Diabetic Nephropathy. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1040322

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1040322