Histone Lysine Methylation in Diabetic Nephropathy
Joint Authors
Cui, Wen-peng
Miao, Lining
Sun, Guang-dong
Guo, Qiao-yan
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Diabetic nephropathy (DN) belongs to debilitating microvascular complications of diabetes and is the leading cause of end-stage renal diseases worldwide.
Furthermore, outcomes from the DCCT/EDIC study showed that DN often persists and progresses despite intensive glucose control in many diabetes patients, possibly as a result of prior episode of hyperglycemia, which is called “metabolic memory.” The underlying mechanisms responsible for the development and progression of DN remain poorly understood.
Activation of multiple signaling pathways and key transcription factors can lead to aberrant expression of DN-related pathologic genes in target renal cells.
Increasing evidence suggests that epigenetic mechanisms in chromatin such as DNA methylation, histone acetylation, and methylation can influence the pathophysiology of DN and metabolic memory.
Exciting researches from cell culture and experimental animals have shown that key histone methylation patterns and the related histone methyltransferases and histone demethylases can play important roles in the regulation of inflammatory and profibrotic genes in renal cells under diabetic conditions.
Because histone methylation is dynamic and potentially reversible, it can provide a window of opportunity for the development of much-needed novel therapeutic potential for DN in the future.
In this minireview, we discuss recent advances in the field of histone methylation and its roles in the pathogenesis and progression of DN.
American Psychological Association (APA)
Sun, Guang-dong& Cui, Wen-peng& Guo, Qiao-yan& Miao, Lining. 2014. Histone Lysine Methylation in Diabetic Nephropathy. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1040322
Modern Language Association (MLA)
Sun, Guang-dong…[et al.]. Histone Lysine Methylation in Diabetic Nephropathy. Journal of Diabetes Research No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1040322
American Medical Association (AMA)
Sun, Guang-dong& Cui, Wen-peng& Guo, Qiao-yan& Miao, Lining. Histone Lysine Methylation in Diabetic Nephropathy. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1040322
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040322