Brain Aging and AD-Like Pathology in Streptozotocin-Induced Diabetic Rats
المؤلفون المشاركون
Wang, Jian-Qin
Yin, Jie
Song, Yan-Feng
Zhang, Lang
Ren, Ying-Xiang
Wang, De-Gui
Gao, Li-Ping
Jing, Yu-Hong
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-14
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Objective.
Numerous epidemiological studies have linked diabetes mellitus (DM) with an increased risk of developing Alzheimer’s disease (AD).
However, whether or not diabetic encephalopathy shows AD-like pathology remains unclear.
Research Design and Methods.
Forebrain and hippocampal volumes were measured using stereology in serial coronal sections of the brain in streptozotocin- (STZ-) induced rats.
Neurodegeneration in the frontal cortex, hypothalamus, and hippocampus was evaluated using Fluoro-Jade C (FJC).
Aβ aggregation in the frontal cortex and hippocampus was tested using immunohistochemistry and ELISA.
Dendritic spine density in the frontal cortex and hippocampus was measured using Golgi staining, and western blot was conducted to detect the levels of synaptophysin.
Cognitive ability was evaluated through the Morris water maze and inhibitory avoidant box.
Results.
Rats are characterized by insulin deficiency accompanied with polydipsia, polyphagia, polyuria, and weight loss after STZ injection.
The number of FJC-positive cells significantly increased in discrete brain regions of the diabetic rats compared with the age-matched control rats.
Hippocampal atrophy, Aβ aggregation, and synapse loss were observed in the diabetic rats compared with the control rats.
The learning and memory of the diabetic rats decreased compared with those of the age-matched control rats.
Conclusions.
Our results suggested that aberrant metabolism induced brain aging as characterized by AD-like pathologies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Jian-Qin& Yin, Jie& Song, Yan-Feng& Zhang, Lang& Ren, Ying-Xiang& Wang, De-Gui…[et al.]. 2014. Brain Aging and AD-Like Pathology in Streptozotocin-Induced Diabetic Rats. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1040374
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Jian-Qin…[et al.]. Brain Aging and AD-Like Pathology in Streptozotocin-Induced Diabetic Rats. Journal of Diabetes Research No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1040374
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Jian-Qin& Yin, Jie& Song, Yan-Feng& Zhang, Lang& Ren, Ying-Xiang& Wang, De-Gui…[et al.]. Brain Aging and AD-Like Pathology in Streptozotocin-Induced Diabetic Rats. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1040374
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1040374
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر