Brain Aging and AD-Like Pathology in Streptozotocin-Induced Diabetic Rats
Joint Authors
Wang, Jian-Qin
Yin, Jie
Song, Yan-Feng
Zhang, Lang
Ren, Ying-Xiang
Wang, De-Gui
Gao, Li-Ping
Jing, Yu-Hong
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-14
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Objective.
Numerous epidemiological studies have linked diabetes mellitus (DM) with an increased risk of developing Alzheimer’s disease (AD).
However, whether or not diabetic encephalopathy shows AD-like pathology remains unclear.
Research Design and Methods.
Forebrain and hippocampal volumes were measured using stereology in serial coronal sections of the brain in streptozotocin- (STZ-) induced rats.
Neurodegeneration in the frontal cortex, hypothalamus, and hippocampus was evaluated using Fluoro-Jade C (FJC).
Aβ aggregation in the frontal cortex and hippocampus was tested using immunohistochemistry and ELISA.
Dendritic spine density in the frontal cortex and hippocampus was measured using Golgi staining, and western blot was conducted to detect the levels of synaptophysin.
Cognitive ability was evaluated through the Morris water maze and inhibitory avoidant box.
Results.
Rats are characterized by insulin deficiency accompanied with polydipsia, polyphagia, polyuria, and weight loss after STZ injection.
The number of FJC-positive cells significantly increased in discrete brain regions of the diabetic rats compared with the age-matched control rats.
Hippocampal atrophy, Aβ aggregation, and synapse loss were observed in the diabetic rats compared with the control rats.
The learning and memory of the diabetic rats decreased compared with those of the age-matched control rats.
Conclusions.
Our results suggested that aberrant metabolism induced brain aging as characterized by AD-like pathologies.
American Psychological Association (APA)
Wang, Jian-Qin& Yin, Jie& Song, Yan-Feng& Zhang, Lang& Ren, Ying-Xiang& Wang, De-Gui…[et al.]. 2014. Brain Aging and AD-Like Pathology in Streptozotocin-Induced Diabetic Rats. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1040374
Modern Language Association (MLA)
Wang, Jian-Qin…[et al.]. Brain Aging and AD-Like Pathology in Streptozotocin-Induced Diabetic Rats. Journal of Diabetes Research No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1040374
American Medical Association (AMA)
Wang, Jian-Qin& Yin, Jie& Song, Yan-Feng& Zhang, Lang& Ren, Ying-Xiang& Wang, De-Gui…[et al.]. Brain Aging and AD-Like Pathology in Streptozotocin-Induced Diabetic Rats. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1040374
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040374