Cytokine-Mediated Bone Destruction in Rheumatoid Arthritis

المؤلفون المشاركون

Yang, Chul Woo
Jung, Seung Min
Kim, Kyoung Woon
Park, Sung-Hwan
Ju, Ji Hyeon

المصدر

Journal of Immunology Research

العدد

المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-15، 15ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2014-09-10

دولة النشر

مصر

عدد الصفحات

15

التخصصات الرئيسية

الأحياء

الملخص EN

Bone homeostasis, which involves formation and resorption, is an important process for maintaining adequate bone mass in humans.

Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammation and bone loss, leading to joint destruction and deformity, and is a representative disease of disrupted bone homeostasis.

The bone loss and joint destruction are mediated by immunological insults by proinflammatory cytokines and various immune cells.

The connection between bone and immunity has been intensely studied and comprises the emerging field of osteoimmunology.

Osteoimmunology is an interdisciplinary science investigating the interplay between the skeletal and the immune systems.

The main contributors in osteoimmunology are the bone effector cells, such as osteoclasts or osteoblasts, and the immune cells, particularly lymphocytes and monocytes.

Physiologically, osteoclasts originate from immune cells, and immune cells regulate osteoblasts and vice versa.

Pathological conditions such as RA might affect these interactions, thereby altering bone homeostasis, resulting in the unfavorable outcome of bone destruction.

In this review, we describe the osteoclastogenic roles of the proinflammatory cytokines and immune cells that are important in the pathophysiology of RA.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Jung, Seung Min& Kim, Kyoung Woon& Yang, Chul Woo& Park, Sung-Hwan& Ju, Ji Hyeon. 2014. Cytokine-Mediated Bone Destruction in Rheumatoid Arthritis. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1040806

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Jung, Seung Min…[et al.]. Cytokine-Mediated Bone Destruction in Rheumatoid Arthritis. Journal of Immunology Research No. 2014 (2014), pp.1-15.
https://search.emarefa.net/detail/BIM-1040806

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Jung, Seung Min& Kim, Kyoung Woon& Yang, Chul Woo& Park, Sung-Hwan& Ju, Ji Hyeon. Cytokine-Mediated Bone Destruction in Rheumatoid Arthritis. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1040806

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1040806