Cytokine-Mediated Bone Destruction in Rheumatoid Arthritis
Joint Authors
Yang, Chul Woo
Jung, Seung Min
Kim, Kyoung Woon
Park, Sung-Hwan
Ju, Ji Hyeon
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-10
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Bone homeostasis, which involves formation and resorption, is an important process for maintaining adequate bone mass in humans.
Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammation and bone loss, leading to joint destruction and deformity, and is a representative disease of disrupted bone homeostasis.
The bone loss and joint destruction are mediated by immunological insults by proinflammatory cytokines and various immune cells.
The connection between bone and immunity has been intensely studied and comprises the emerging field of osteoimmunology.
Osteoimmunology is an interdisciplinary science investigating the interplay between the skeletal and the immune systems.
The main contributors in osteoimmunology are the bone effector cells, such as osteoclasts or osteoblasts, and the immune cells, particularly lymphocytes and monocytes.
Physiologically, osteoclasts originate from immune cells, and immune cells regulate osteoblasts and vice versa.
Pathological conditions such as RA might affect these interactions, thereby altering bone homeostasis, resulting in the unfavorable outcome of bone destruction.
In this review, we describe the osteoclastogenic roles of the proinflammatory cytokines and immune cells that are important in the pathophysiology of RA.
American Psychological Association (APA)
Jung, Seung Min& Kim, Kyoung Woon& Yang, Chul Woo& Park, Sung-Hwan& Ju, Ji Hyeon. 2014. Cytokine-Mediated Bone Destruction in Rheumatoid Arthritis. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1040806
Modern Language Association (MLA)
Jung, Seung Min…[et al.]. Cytokine-Mediated Bone Destruction in Rheumatoid Arthritis. Journal of Immunology Research No. 2014 (2014), pp.1-15.
https://search.emarefa.net/detail/BIM-1040806
American Medical Association (AMA)
Jung, Seung Min& Kim, Kyoung Woon& Yang, Chul Woo& Park, Sung-Hwan& Ju, Ji Hyeon. Cytokine-Mediated Bone Destruction in Rheumatoid Arthritis. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1040806
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040806