The Role of PAM4 in the Management of Pancreatic Cancer: Diagnosis, Radioimmunodetection, and Radioimmunotherapy

المؤلفون المشاركون

Han, Su-xia
Jin, Gui-hua
He, Chen-chen
Guo, Xi-jing
Wang, Li-juan
Li, Meng
Zhu, Qing

المصدر

Journal of Immunology Research

العدد

المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2014-04-10

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الأحياء

الملخص EN

PAM4, a new monoclonal antibody (MAb) known as clivatuzumab, is highly reactive with pancreatic cancer and precursor lesions.

It is absent from the normal tissues and has limited reactivity with nonpancreatic cancer.

The detailed characteristic of the PAM4 epitope is unknown but recent studies have shown that it is dependent on MUC1 glycosylation status.

The limited PAM4 expression pattern makes it an attractive candidate for management of pancreatic adenocarcinoma.

In addition, PAM4 is a serum biomarker for diagnosis of pancreatic cancer.

Several different radiolabeled immunodiagnostic and immunotherapeutic agents of PAM4 have been developed and some are being evaluated in preclinical and/or clinical studies.

The review will focus on PAM4 and its potential utility for the diagnosis, radioimmunodetection, and radioimmunotherapy of pancreatic cancer.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Han, Su-xia& Jin, Gui-hua& Wang, Li-juan& Li, Meng& He, Chen-chen& Guo, Xi-jing…[et al.]. 2014. The Role of PAM4 in the Management of Pancreatic Cancer: Diagnosis, Radioimmunodetection, and Radioimmunotherapy. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1040808

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Han, Su-xia…[et al.]. The Role of PAM4 in the Management of Pancreatic Cancer: Diagnosis, Radioimmunodetection, and Radioimmunotherapy. Journal of Immunology Research No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1040808

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Han, Su-xia& Jin, Gui-hua& Wang, Li-juan& Li, Meng& He, Chen-chen& Guo, Xi-jing…[et al.]. The Role of PAM4 in the Management of Pancreatic Cancer: Diagnosis, Radioimmunodetection, and Radioimmunotherapy. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1040808

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1040808