The Role of PAM4 in the Management of Pancreatic Cancer: Diagnosis, Radioimmunodetection, and Radioimmunotherapy
Joint Authors
Han, Su-xia
Jin, Gui-hua
He, Chen-chen
Guo, Xi-jing
Wang, Li-juan
Li, Meng
Zhu, Qing
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
PAM4, a new monoclonal antibody (MAb) known as clivatuzumab, is highly reactive with pancreatic cancer and precursor lesions.
It is absent from the normal tissues and has limited reactivity with nonpancreatic cancer.
The detailed characteristic of the PAM4 epitope is unknown but recent studies have shown that it is dependent on MUC1 glycosylation status.
The limited PAM4 expression pattern makes it an attractive candidate for management of pancreatic adenocarcinoma.
In addition, PAM4 is a serum biomarker for diagnosis of pancreatic cancer.
Several different radiolabeled immunodiagnostic and immunotherapeutic agents of PAM4 have been developed and some are being evaluated in preclinical and/or clinical studies.
The review will focus on PAM4 and its potential utility for the diagnosis, radioimmunodetection, and radioimmunotherapy of pancreatic cancer.
American Psychological Association (APA)
Han, Su-xia& Jin, Gui-hua& Wang, Li-juan& Li, Meng& He, Chen-chen& Guo, Xi-jing…[et al.]. 2014. The Role of PAM4 in the Management of Pancreatic Cancer: Diagnosis, Radioimmunodetection, and Radioimmunotherapy. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1040808
Modern Language Association (MLA)
Han, Su-xia…[et al.]. The Role of PAM4 in the Management of Pancreatic Cancer: Diagnosis, Radioimmunodetection, and Radioimmunotherapy. Journal of Immunology Research No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1040808
American Medical Association (AMA)
Han, Su-xia& Jin, Gui-hua& Wang, Li-juan& Li, Meng& He, Chen-chen& Guo, Xi-jing…[et al.]. The Role of PAM4 in the Management of Pancreatic Cancer: Diagnosis, Radioimmunodetection, and Radioimmunotherapy. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1040808
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040808
