Appropriate Development of the Liver Treg Compartment Is Modulated by the Microbiota and Requires TGF-β and MyD88
المؤلفون المشاركون
Maria, Ann
English, Kathryn A.
Gorham, James D.
المصدر
Journal of Immunology Research
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-07
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Neither the early postnatal development of the liver Treg compartment nor the factors that regulate its development has been characterized.
We compared the early developmental patterns of Treg cell accumulation in murine liver, thymus, and spleen.
A FoxP3EGFP reporter mouse was employed to identify Treg cells.
Mononuclear cells were isolated from organs postnatally, stained for CD4, and examined by flow cytometry to enumerate FoxP3+ CD4 hi cells.
To assess roles for TGF- β 1 , MyD88, and TLR2, gene-specific knockout pups were generated from heterozygous breeders.
To test the role of commensal bacteria, pregnant dams were administered antibiotics during gestation and after parturition.
The pattern of appearance of Treg cells differed in liver, spleen, and thymus.
Notably, at 1-2 weeks, the frequency of CD4 hi FoxP3+ T cells in liver exceeded that in spleen by 1.5- to 2-fold.
The relative increase in liver Treg frequency was transient and was dependent upon TGF- β 1 and MyD88, but not TLR2, and was abrogated by antibiotic treatment.
A relative increase in liver Treg frequency occurs approximately 1-2 weeks after parturition that appears to be driven by colonization of the intestine with commensal bacteria and is mediated by a pathway that requires TGF- β 1 and MyD88, but not TLR2.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Maria, Ann& English, Kathryn A.& Gorham, James D.. 2014. Appropriate Development of the Liver Treg Compartment Is Modulated by the Microbiota and Requires TGF-β and MyD88. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1040820
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Maria, Ann…[et al.]. Appropriate Development of the Liver Treg Compartment Is Modulated by the Microbiota and Requires TGF-β and MyD88. Journal of Immunology Research No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1040820
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Maria, Ann& English, Kathryn A.& Gorham, James D.. Appropriate Development of the Liver Treg Compartment Is Modulated by the Microbiota and Requires TGF-β and MyD88. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1040820
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1040820
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر