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Palladium Nanoparticles Induce Disturbances in Cell Cycle Entry and Progression of Peripheral Blood Mononuclear Cells: Paramount Role of Ions
المؤلفون المشاركون
Bernardini, Giovanni
Petrarca, Claudia
Clemente, Emanuela
Di Giampaolo, Luca
Leopold, Kerstin
Schindl, Roland
Lotti, Lavinia V.
Mangifesta, Rocco
Sabbioni, Enrico
Niu, Qiao
Di Gioacchino, Mario
Mariani-Costantini, Renato
المصدر
Journal of Immunology Research
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-03
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
There is concern about the possible toxicity of palladium nanoparticles (Pd-NP), as they are released in the environment through many applications.
We previously studied the toxicity of Pd-NP at high concentrations; here we address the possible toxicity of Pd-NP at low, subtoxic doses.
In particular, we have exposed normal human PBMC entering into the first in vitro mitotic division to Pd-NP and to Pd(IV) ions to evaluate ROS generation and cell cycle progression.
We have measured a statistically significant increase of intracellular ROS in Pd(IV) exposed cells, but not in Pd-NP exposed cells.
TEM revealed accumulation of lipid droplets and autophagic and mitophagic vacuoles, which appeared more conspicuous in cells exposed to Pd(IV) ions than to Pd-NP.
Pd-NP were visible in the cytoplasm of Pd-NP exposed cells.
Pd-NP addition was associated with a significant increase of cells within the G0/G1-phase and a significant reduction in GS- and G2/M-phases.
Cells exposed to Pd(IV) ions showed a significant amplification of these cell cycle alterations.
These results suggest that ions, per se or released by NPs, are the true inducers of Pd toxicity.
It will be essential to verify whether the observed disturbance represents a temporary response or might result in permanent alterations.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Petrarca, Claudia& Clemente, Emanuela& Di Giampaolo, Luca& Mariani-Costantini, Renato& Leopold, Kerstin& Schindl, Roland…[et al.]. 2014. Palladium Nanoparticles Induce Disturbances in Cell Cycle Entry and Progression of Peripheral Blood Mononuclear Cells: Paramount Role of Ions. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1040826
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Petrarca, Claudia…[et al.]. Palladium Nanoparticles Induce Disturbances in Cell Cycle Entry and Progression of Peripheral Blood Mononuclear Cells: Paramount Role of Ions. Journal of Immunology Research No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1040826
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Petrarca, Claudia& Clemente, Emanuela& Di Giampaolo, Luca& Mariani-Costantini, Renato& Leopold, Kerstin& Schindl, Roland…[et al.]. Palladium Nanoparticles Induce Disturbances in Cell Cycle Entry and Progression of Peripheral Blood Mononuclear Cells: Paramount Role of Ions. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1040826
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1040826
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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