Analysis of Autoantibodies to 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Using Different Technologies
المؤلفون المشاركون
Benveniste, Olivier
Shikhman, Alexander
Boyer, Olivier
Fowler, Richard
Mammen, Andrew
Phillips, Joe
Musset, Lucile
Charuel, Jean-Luc
Mahler, Michael
Miyara, Makoto
المصدر
Journal of Immunology Research
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-04
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Diagnostic tests are needed to aid in the diagnosis of necrotizing myopathies associated with statin use.
This study aimed to compare different technologies for the detection of anti-HMGCR antibodies and analyze the clinical phenotype and autoantibody profile of the patients.
Twenty samples from myositis patients positive for anti-HMGCR antibodies using a research addressable laser bead assay and 20 negative controls were tested for autoantibodies to HMGCR: QUANTA Lite HMGCR ELISA and QUANTA Flash HMGCR CIA.
All patients were also tested for antibodies to extractable nuclear antigens and myositis related antibodies.
To verify the specificity of the ELISA, 824 controls were tested.
All three assays showed qualitative agreements of 100% and levels of anti-HMGCR antibodies showed significant correlation: Spearman’s rho > 0.8.
The mean age of the anti-HMGCR antibody positive patients was 54.4 years, 16/20 were females, and 18/20 had necrotizing myopathy (two patients were not diagnosed).
Nine out of 20 anti-HMGCR positive patients were on statin.
All patients with anti-HMGCR antibodies were negative for all other autoantibodies tested.
Testing various controls showed high specificity (99.3%).
Anti-HMGCR antibodies are not always associated with the use of statin and appear to be the exclusive autoantibody specificity in patients with statin associated myopathies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Musset, Lucile& Miyara, Makoto& Benveniste, Olivier& Charuel, Jean-Luc& Shikhman, Alexander& Boyer, Olivier…[et al.]. 2014. Analysis of Autoantibodies to 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Using Different Technologies. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1040865
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Musset, Lucile…[et al.]. Analysis of Autoantibodies to 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Using Different Technologies. Journal of Immunology Research No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1040865
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Musset, Lucile& Miyara, Makoto& Benveniste, Olivier& Charuel, Jean-Luc& Shikhman, Alexander& Boyer, Olivier…[et al.]. Analysis of Autoantibodies to 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Using Different Technologies. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1040865
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1040865
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر