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Analysis of Autoantibodies to 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Using Different Technologies
Joint Authors
Benveniste, Olivier
Shikhman, Alexander
Boyer, Olivier
Fowler, Richard
Mammen, Andrew
Phillips, Joe
Musset, Lucile
Charuel, Jean-Luc
Mahler, Michael
Miyara, Makoto
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Diagnostic tests are needed to aid in the diagnosis of necrotizing myopathies associated with statin use.
This study aimed to compare different technologies for the detection of anti-HMGCR antibodies and analyze the clinical phenotype and autoantibody profile of the patients.
Twenty samples from myositis patients positive for anti-HMGCR antibodies using a research addressable laser bead assay and 20 negative controls were tested for autoantibodies to HMGCR: QUANTA Lite HMGCR ELISA and QUANTA Flash HMGCR CIA.
All patients were also tested for antibodies to extractable nuclear antigens and myositis related antibodies.
To verify the specificity of the ELISA, 824 controls were tested.
All three assays showed qualitative agreements of 100% and levels of anti-HMGCR antibodies showed significant correlation: Spearman’s rho > 0.8.
The mean age of the anti-HMGCR antibody positive patients was 54.4 years, 16/20 were females, and 18/20 had necrotizing myopathy (two patients were not diagnosed).
Nine out of 20 anti-HMGCR positive patients were on statin.
All patients with anti-HMGCR antibodies were negative for all other autoantibodies tested.
Testing various controls showed high specificity (99.3%).
Anti-HMGCR antibodies are not always associated with the use of statin and appear to be the exclusive autoantibody specificity in patients with statin associated myopathies.
American Psychological Association (APA)
Musset, Lucile& Miyara, Makoto& Benveniste, Olivier& Charuel, Jean-Luc& Shikhman, Alexander& Boyer, Olivier…[et al.]. 2014. Analysis of Autoantibodies to 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Using Different Technologies. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1040865
Modern Language Association (MLA)
Musset, Lucile…[et al.]. Analysis of Autoantibodies to 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Using Different Technologies. Journal of Immunology Research No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1040865
American Medical Association (AMA)
Musset, Lucile& Miyara, Makoto& Benveniste, Olivier& Charuel, Jean-Luc& Shikhman, Alexander& Boyer, Olivier…[et al.]. Analysis of Autoantibodies to 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Using Different Technologies. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1040865
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040865