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Complement System in Pathogenesis of AMD: Dual Player in Degeneration and Protection of Retinal Tissue
المؤلفون المشاركون
Kawa, Milosz P.
Machalinska, Anna
Roginska, Dorota
Machalinski, Boguslaw
المصدر
Journal of Immunology Research
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-09-03
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Age-related macular degeneration (AMD) is the most common cause of blindness among the elderly, especially in Western countries.
Although the prevalence, risk factors, and clinical course of the disease are well described, its pathogenesis is not entirely elucidated.
AMD is associated with a variety of biochemical abnormalities, including complement components deposition in the retinal pigment epithelium-Bruch’s membrane-choriocapillaris complex.
Although the complement system (CS) is increasingly recognized as mediating important roles in retinal biology, its particular role in AMD pathogenesis has not been precisely defined.
Unrestricted activation of the CS following injury may directly damage retinal tissue and recruit immune cells to the vicinity of active complement cascades, therefore detrimentally causing bystander damage to surrounding cells and tissues.
On the other hand, recent evidence supports the notion that an active complement pathway is a necessity for the normal maintenance of the neurosensory retina.
In this scenario, complement activation appears to have beneficial effect as it promotes cell survival and tissue remodeling by facilitating the rapid removal of dying cells and resulting cellular debris, thus demonstrating anti-inflammatory and neuroprotective activities.
In this review, we discuss both the beneficial and detrimental roles of CS in degenerative retina, focusing on the diverse aspects of CS functions that may promote or inhibit macular disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kawa, Milosz P.& Machalinska, Anna& Roginska, Dorota& Machalinski, Boguslaw. 2014. Complement System in Pathogenesis of AMD: Dual Player in Degeneration and Protection of Retinal Tissue. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1040878
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kawa, Milosz P.…[et al.]. Complement System in Pathogenesis of AMD: Dual Player in Degeneration and Protection of Retinal Tissue. Journal of Immunology Research No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1040878
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kawa, Milosz P.& Machalinska, Anna& Roginska, Dorota& Machalinski, Boguslaw. Complement System in Pathogenesis of AMD: Dual Player in Degeneration and Protection of Retinal Tissue. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1040878
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1040878
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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