Complement System in Pathogenesis of AMD: Dual Player in Degeneration and Protection of Retinal Tissue
Joint Authors
Kawa, Milosz P.
Machalinska, Anna
Roginska, Dorota
Machalinski, Boguslaw
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-03
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Age-related macular degeneration (AMD) is the most common cause of blindness among the elderly, especially in Western countries.
Although the prevalence, risk factors, and clinical course of the disease are well described, its pathogenesis is not entirely elucidated.
AMD is associated with a variety of biochemical abnormalities, including complement components deposition in the retinal pigment epithelium-Bruch’s membrane-choriocapillaris complex.
Although the complement system (CS) is increasingly recognized as mediating important roles in retinal biology, its particular role in AMD pathogenesis has not been precisely defined.
Unrestricted activation of the CS following injury may directly damage retinal tissue and recruit immune cells to the vicinity of active complement cascades, therefore detrimentally causing bystander damage to surrounding cells and tissues.
On the other hand, recent evidence supports the notion that an active complement pathway is a necessity for the normal maintenance of the neurosensory retina.
In this scenario, complement activation appears to have beneficial effect as it promotes cell survival and tissue remodeling by facilitating the rapid removal of dying cells and resulting cellular debris, thus demonstrating anti-inflammatory and neuroprotective activities.
In this review, we discuss both the beneficial and detrimental roles of CS in degenerative retina, focusing on the diverse aspects of CS functions that may promote or inhibit macular disease.
American Psychological Association (APA)
Kawa, Milosz P.& Machalinska, Anna& Roginska, Dorota& Machalinski, Boguslaw. 2014. Complement System in Pathogenesis of AMD: Dual Player in Degeneration and Protection of Retinal Tissue. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1040878
Modern Language Association (MLA)
Kawa, Milosz P.…[et al.]. Complement System in Pathogenesis of AMD: Dual Player in Degeneration and Protection of Retinal Tissue. Journal of Immunology Research No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1040878
American Medical Association (AMA)
Kawa, Milosz P.& Machalinska, Anna& Roginska, Dorota& Machalinski, Boguslaw. Complement System in Pathogenesis of AMD: Dual Player in Degeneration and Protection of Retinal Tissue. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1040878
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040878