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Insight into Gene Polymorphisms Involved in Toll-Like ReceptorInterferon Signalling Pathways for Systemic Lupus Erythematosus in South East Asia
المؤلفون المشاركون
Chua, Kek Heng
Lim, Soo Kun
Phipps, Maude Elvira
Chai, Hwa Chia
المصدر
Journal of Immunology Research
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-17
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Polymorphisms in genes involved in toll-like receptor/interferon signalling pathways have been reported previously to be associated with SLE in many populations.
This study aimed to investigate the role of seven single nucleotide polymorphisms within TNFAIP3, STAT4, and IRF5, which are involved in upstream and downstream pathways of type I interferon production, in SLE in the South East Asian populations.
Genotyping of 360 Malaysian SLE patients and 430 normal healthy individuals revealed that minor alleles of STAT4 rs7574865 and rs10168266 were associated with elevated risk of SLE in the Chinese and Malay patients, respectively (P=0.028, odds ratio (OR)=1.42; P=0.035, OR=1.80, respectively).
Polymorphisms in TNFAIP3 and IRF5 did not show significant associations with SLE in any of the ethnicities.
Combined analysis of the Malays, Chinese, and Indians for each SNP indicated that STAT4 rs10168266 was significantly associated with the Malaysian SLE as a whole (P=0.014; OR=1.435).
The meta-analysis of STAT4 rs10168266, which combined the data of other studies and this study, further confirmed its importance as the risk factor for SLE by having pooled OR of 1.559 and P value of <0.001.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chai, Hwa Chia& Chua, Kek Heng& Lim, Soo Kun& Phipps, Maude Elvira. 2014. Insight into Gene Polymorphisms Involved in Toll-Like ReceptorInterferon Signalling Pathways for Systemic Lupus Erythematosus in South East Asia. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1040887
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chai, Hwa Chia…[et al.]. Insight into Gene Polymorphisms Involved in Toll-Like ReceptorInterferon Signalling Pathways for Systemic Lupus Erythematosus in South East Asia. Journal of Immunology Research No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1040887
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chai, Hwa Chia& Chua, Kek Heng& Lim, Soo Kun& Phipps, Maude Elvira. Insight into Gene Polymorphisms Involved in Toll-Like ReceptorInterferon Signalling Pathways for Systemic Lupus Erythematosus in South East Asia. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1040887
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1040887
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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