![](/images/graphics-bg.png)
Insight into Gene Polymorphisms Involved in Toll-Like ReceptorInterferon Signalling Pathways for Systemic Lupus Erythematosus in South East Asia
Joint Authors
Chua, Kek Heng
Lim, Soo Kun
Phipps, Maude Elvira
Chai, Hwa Chia
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Polymorphisms in genes involved in toll-like receptor/interferon signalling pathways have been reported previously to be associated with SLE in many populations.
This study aimed to investigate the role of seven single nucleotide polymorphisms within TNFAIP3, STAT4, and IRF5, which are involved in upstream and downstream pathways of type I interferon production, in SLE in the South East Asian populations.
Genotyping of 360 Malaysian SLE patients and 430 normal healthy individuals revealed that minor alleles of STAT4 rs7574865 and rs10168266 were associated with elevated risk of SLE in the Chinese and Malay patients, respectively (P=0.028, odds ratio (OR)=1.42; P=0.035, OR=1.80, respectively).
Polymorphisms in TNFAIP3 and IRF5 did not show significant associations with SLE in any of the ethnicities.
Combined analysis of the Malays, Chinese, and Indians for each SNP indicated that STAT4 rs10168266 was significantly associated with the Malaysian SLE as a whole (P=0.014; OR=1.435).
The meta-analysis of STAT4 rs10168266, which combined the data of other studies and this study, further confirmed its importance as the risk factor for SLE by having pooled OR of 1.559 and P value of <0.001.
American Psychological Association (APA)
Chai, Hwa Chia& Chua, Kek Heng& Lim, Soo Kun& Phipps, Maude Elvira. 2014. Insight into Gene Polymorphisms Involved in Toll-Like ReceptorInterferon Signalling Pathways for Systemic Lupus Erythematosus in South East Asia. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1040887
Modern Language Association (MLA)
Chai, Hwa Chia…[et al.]. Insight into Gene Polymorphisms Involved in Toll-Like ReceptorInterferon Signalling Pathways for Systemic Lupus Erythematosus in South East Asia. Journal of Immunology Research No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1040887
American Medical Association (AMA)
Chai, Hwa Chia& Chua, Kek Heng& Lim, Soo Kun& Phipps, Maude Elvira. Insight into Gene Polymorphisms Involved in Toll-Like ReceptorInterferon Signalling Pathways for Systemic Lupus Erythematosus in South East Asia. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1040887
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040887