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Distribution of HLA-A, -B, and -C Alleles and HLAKIR Combinations in Han Population in China
المؤلفون المشاركون
Kulski, Jerzy K.
Shen, Yunsong
Cao, Danfeng
Li, Yalin
Shi, Lei
Jiang, Hongjun
Ma, Qianli
Yu, Jiankun
Zhou, Jingxian
Yao, Yufeng
Shi, Li
المصدر
Journal of Immunology Research
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-05
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
We investigated polymorphisms of the human leukocyte antigen (HLA) class I (A, B, and C) loci of a Han population (n, 239) from the Yunnan province, Southwest China, using high-resolution polymerase chain reaction-Luminex (PCR-Luminex) typing.
We combined the HLA data from this study with the KIR genotypes from a previous study of this Han population to analyze the combination of KIR/HLA ligands.
A total of 27 HLA-A, 54 HLA-B, and 31 HLA-C alleles were found in this population.
The frequencies of A*11:01, A*24:02, B*40:01, B*46:01, C*01:02, C*03:04, and C*07:02 were all > 10%.
The following haplotypes were common, with frequencies > 5%: 1 A-B (A*02:07-B*46:01), 2 A-C (A*02:07-C*01:02, and A*11:01-C*07:02), 4 C-B (B*13:01-C*03:04, B*40:01-C*07:02, B*46:01-C*01:02 and B*58:01-C*03:02), and 1 A-C-B (A*02:07-C*01:02-B*46:01).
Analysis of KIR3D and their ligands HLA-A3/A11 and HLA-Bw4 showed that the frequencies of 3DL2+-A3/A11+ and 3DL2+-A3/A11− were 0.527 and 0.473, and the frequencies of 3DL1+-Bw4+, 3DL1+-Bw4−, 3DL1−-Bw4+, and 3DL1−-Bw4− were 0.552, 0.397, 0.038, and 0.013, respectively.
The results of KIR/HLA-C combination analysis showed that all individuals had at least one inhibitory or activating KIR/HLA-C pair, and one KIR/HLA-C pair was the most frequent (157/239), followed by two pairs (46/239), three pairs (33/239), and no pairs (3/239).
Comparison of KIR gene and HLA gene and their pair frequency between Yunnan Han and the isolated Han (FYDH) who also lived in Yunnan province showed no significant difference (P>0.05) in KIR frequencies, but significant differences (P<0.05) for some HLA allele frequencies.
In addition, there was no significant difference (P>0.05) between the two populations for KIR/HLA pairs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shen, Yunsong& Cao, Danfeng& Li, Yalin& Kulski, Jerzy K.& Shi, Lei& Jiang, Hongjun…[et al.]. 2014. Distribution of HLA-A, -B, and -C Alleles and HLAKIR Combinations in Han Population in China. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1040894
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shen, Yunsong…[et al.]. Distribution of HLA-A, -B, and -C Alleles and HLAKIR Combinations in Han Population in China. Journal of Immunology Research No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1040894
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shen, Yunsong& Cao, Danfeng& Li, Yalin& Kulski, Jerzy K.& Shi, Lei& Jiang, Hongjun…[et al.]. Distribution of HLA-A, -B, and -C Alleles and HLAKIR Combinations in Han Population in China. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1040894
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1040894
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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