Distribution of HLA-A, -B, and -C Alleles and HLAKIR Combinations in Han Population in China
Joint Authors
Kulski, Jerzy K.
Shen, Yunsong
Cao, Danfeng
Li, Yalin
Shi, Lei
Jiang, Hongjun
Ma, Qianli
Yu, Jiankun
Zhou, Jingxian
Yao, Yufeng
Shi, Li
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We investigated polymorphisms of the human leukocyte antigen (HLA) class I (A, B, and C) loci of a Han population (n, 239) from the Yunnan province, Southwest China, using high-resolution polymerase chain reaction-Luminex (PCR-Luminex) typing.
We combined the HLA data from this study with the KIR genotypes from a previous study of this Han population to analyze the combination of KIR/HLA ligands.
A total of 27 HLA-A, 54 HLA-B, and 31 HLA-C alleles were found in this population.
The frequencies of A*11:01, A*24:02, B*40:01, B*46:01, C*01:02, C*03:04, and C*07:02 were all > 10%.
The following haplotypes were common, with frequencies > 5%: 1 A-B (A*02:07-B*46:01), 2 A-C (A*02:07-C*01:02, and A*11:01-C*07:02), 4 C-B (B*13:01-C*03:04, B*40:01-C*07:02, B*46:01-C*01:02 and B*58:01-C*03:02), and 1 A-C-B (A*02:07-C*01:02-B*46:01).
Analysis of KIR3D and their ligands HLA-A3/A11 and HLA-Bw4 showed that the frequencies of 3DL2+-A3/A11+ and 3DL2+-A3/A11− were 0.527 and 0.473, and the frequencies of 3DL1+-Bw4+, 3DL1+-Bw4−, 3DL1−-Bw4+, and 3DL1−-Bw4− were 0.552, 0.397, 0.038, and 0.013, respectively.
The results of KIR/HLA-C combination analysis showed that all individuals had at least one inhibitory or activating KIR/HLA-C pair, and one KIR/HLA-C pair was the most frequent (157/239), followed by two pairs (46/239), three pairs (33/239), and no pairs (3/239).
Comparison of KIR gene and HLA gene and their pair frequency between Yunnan Han and the isolated Han (FYDH) who also lived in Yunnan province showed no significant difference (P>0.05) in KIR frequencies, but significant differences (P<0.05) for some HLA allele frequencies.
In addition, there was no significant difference (P>0.05) between the two populations for KIR/HLA pairs.
American Psychological Association (APA)
Shen, Yunsong& Cao, Danfeng& Li, Yalin& Kulski, Jerzy K.& Shi, Lei& Jiang, Hongjun…[et al.]. 2014. Distribution of HLA-A, -B, and -C Alleles and HLAKIR Combinations in Han Population in China. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1040894
Modern Language Association (MLA)
Shen, Yunsong…[et al.]. Distribution of HLA-A, -B, and -C Alleles and HLAKIR Combinations in Han Population in China. Journal of Immunology Research No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1040894
American Medical Association (AMA)
Shen, Yunsong& Cao, Danfeng& Li, Yalin& Kulski, Jerzy K.& Shi, Lei& Jiang, Hongjun…[et al.]. Distribution of HLA-A, -B, and -C Alleles and HLAKIR Combinations in Han Population in China. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1040894
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040894