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Identification of Osteosarcoma-Related Specific Proteins in Serum Samples Using Surface-Enhanced Laser DesorptionIonization-Time-of-Flight Mass Spectrometry
المؤلفون المشاركون
Gu, Jianli
Li, Jitian
Huang, Manyu
Zhang, Zhiyong
Li, Dongsheng
Song, Guoying
Ding, Xingpo
Li, Wuyin
المصدر
Journal of Immunology Research
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-24
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Osteosarcoma (OS) is the most common malignant bone tumor.
To identify OS-related specific proteins for early diagnosis of OS, a novel approach, surface-enhanced laser desorption/ionization-time-of-flight mass spectrometry (SELDI-TOF-MS) to serum samples from 25 OS patients, 16 osteochondroma, and 26 age-matched normal human volunteers as controls, was performed.
Two proteins showed a significantly different expression in OS serum samples from control groups.
Proteomic profiles and external leave-one-out cross-validation analysis showed that the correct rate of allocation, the sensitivity, and the specificity of diagnosis were 100%.
These two proteins were further identified by searching the EPO-KB database, and one of the proteins identified as Serine rich region profile is involved in various cellular signaling cascades and tumor genesis.
The presence of these two proteins in OS patients but absence from premalignant and normal human controls implied that they can be potential biomarkers for early diagnosis of OS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gu, Jianli& Li, Jitian& Huang, Manyu& Zhang, Zhiyong& Li, Dongsheng& Song, Guoying…[et al.]. 2014. Identification of Osteosarcoma-Related Specific Proteins in Serum Samples Using Surface-Enhanced Laser DesorptionIonization-Time-of-Flight Mass Spectrometry. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1040934
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gu, Jianli…[et al.]. Identification of Osteosarcoma-Related Specific Proteins in Serum Samples Using Surface-Enhanced Laser DesorptionIonization-Time-of-Flight Mass Spectrometry. Journal of Immunology Research No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1040934
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gu, Jianli& Li, Jitian& Huang, Manyu& Zhang, Zhiyong& Li, Dongsheng& Song, Guoying…[et al.]. Identification of Osteosarcoma-Related Specific Proteins in Serum Samples Using Surface-Enhanced Laser DesorptionIonization-Time-of-Flight Mass Spectrometry. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1040934
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1040934
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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