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Increased Frequency of Circulating Follicular Helper T Cells in Children with Hand, Foot, and Mouth Disease Caused by Enterovirus 71 Infection
المؤلفون المشاركون
Wu, Jianping
Cui, David
Yang, Xianzhi
Lou, Jianzhou
Lin, Jie
Ye, Xianfei
Qin, Zhimei
Huang, Li
Zhao, Dejian
Huo, Zhaoxia
Xie, Guoliang
Zheng, Shufa
Yu, Fei
Lu, Liwei
Chen, Yu
المصدر
Journal of Immunology Research
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-11
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Enterovirus 71 (EV71) is a major causative agent of hand, foot, and mouth disease (HFMD) in children.
The role of T follicular helper (TFH) cells in EV71-infected children remains unclear in regulating humoral immunity.
The frequency of circulating ICOShigh/PD-1highCXCR5+CD4+ TFH cells in the children with mild and severe EV71 infection and healthy controls (HC) was detected by flow cytometry, respectively.
IL-21 and IL-6 mRNA expression and their serum levels, Bcl-6 mRNA expression, and specific neutralizing antibodies against EV71 (NAb-EV71) were measured.
In the acute stage of patients with EV71 infection, increased frequencies of circulating TFH cells with ICOShigh and PD-1high expression in the mild and severe patients were observed, and the positive correlations among the frequencies of circulating TFH cells and the serum levels of IL-21, IL-6, and NAb-EV71 titres were detected, respectively.
Moreover, the expressions of IL-6 and IL-21 mRNA in PBMCs from patients were also significantly higher than those of HC.
However, further analysis did not reveal any significant differences between mild and severe patients.
These data indicate a role of TFH cells and associated cytokines in modulating the humoral response during the pathogenesis of EV71 infection.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Jianping& Cui, David& Yang, Xianzhi& Lou, Jianzhou& Lin, Jie& Ye, Xianfei…[et al.]. 2014. Increased Frequency of Circulating Follicular Helper T Cells in Children with Hand, Foot, and Mouth Disease Caused by Enterovirus 71 Infection. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1040935
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Jianping…[et al.]. Increased Frequency of Circulating Follicular Helper T Cells in Children with Hand, Foot, and Mouth Disease Caused by Enterovirus 71 Infection. Journal of Immunology Research No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1040935
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Jianping& Cui, David& Yang, Xianzhi& Lou, Jianzhou& Lin, Jie& Ye, Xianfei…[et al.]. Increased Frequency of Circulating Follicular Helper T Cells in Children with Hand, Foot, and Mouth Disease Caused by Enterovirus 71 Infection. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1040935
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1040935
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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