Increased Frequency of Circulating Follicular Helper T Cells in Children with Hand, Foot, and Mouth Disease Caused by Enterovirus 71 Infection
Joint Authors
Wu, Jianping
Cui, David
Yang, Xianzhi
Lou, Jianzhou
Lin, Jie
Ye, Xianfei
Qin, Zhimei
Huang, Li
Zhao, Dejian
Huo, Zhaoxia
Xie, Guoliang
Zheng, Shufa
Yu, Fei
Lu, Liwei
Chen, Yu
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Enterovirus 71 (EV71) is a major causative agent of hand, foot, and mouth disease (HFMD) in children.
The role of T follicular helper (TFH) cells in EV71-infected children remains unclear in regulating humoral immunity.
The frequency of circulating ICOShigh/PD-1highCXCR5+CD4+ TFH cells in the children with mild and severe EV71 infection and healthy controls (HC) was detected by flow cytometry, respectively.
IL-21 and IL-6 mRNA expression and their serum levels, Bcl-6 mRNA expression, and specific neutralizing antibodies against EV71 (NAb-EV71) were measured.
In the acute stage of patients with EV71 infection, increased frequencies of circulating TFH cells with ICOShigh and PD-1high expression in the mild and severe patients were observed, and the positive correlations among the frequencies of circulating TFH cells and the serum levels of IL-21, IL-6, and NAb-EV71 titres were detected, respectively.
Moreover, the expressions of IL-6 and IL-21 mRNA in PBMCs from patients were also significantly higher than those of HC.
However, further analysis did not reveal any significant differences between mild and severe patients.
These data indicate a role of TFH cells and associated cytokines in modulating the humoral response during the pathogenesis of EV71 infection.
American Psychological Association (APA)
Wu, Jianping& Cui, David& Yang, Xianzhi& Lou, Jianzhou& Lin, Jie& Ye, Xianfei…[et al.]. 2014. Increased Frequency of Circulating Follicular Helper T Cells in Children with Hand, Foot, and Mouth Disease Caused by Enterovirus 71 Infection. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1040935
Modern Language Association (MLA)
Wu, Jianping…[et al.]. Increased Frequency of Circulating Follicular Helper T Cells in Children with Hand, Foot, and Mouth Disease Caused by Enterovirus 71 Infection. Journal of Immunology Research No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1040935
American Medical Association (AMA)
Wu, Jianping& Cui, David& Yang, Xianzhi& Lou, Jianzhou& Lin, Jie& Ye, Xianfei…[et al.]. Increased Frequency of Circulating Follicular Helper T Cells in Children with Hand, Foot, and Mouth Disease Caused by Enterovirus 71 Infection. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1040935
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040935