Uncomplicated Diverticular Disease: Innate and Adaptive Immunity in Human Gut Mucosa before and after Rifaximin
المؤلفون المشاركون
Cianci, Rossella
Cianci, R.
Frosali, Simona
Cesaro, Paola
Petruzziello, Lucio
Casciano, Fabio
Costamagna, Guido
Landolfi, R.
Pandolfi, Franco
المصدر
Journal of Immunology Research
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-16
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background/Aim.
Uncomplicated diverticular disease (UDD) is a frequent condition in adults.
The pathogenesis of symptoms remains unknown.
Bacteria are able to interact with Toll-like receptors (TLRs) and to induce inflammation through both innate immunity and T-cell recruitment.
We investigated the pattern of TLRs 2 and 4 and the intestinal homing in patients with UDD before and after a course of Rifaximin.
Methods.
Forty consecutive patients with UDD and 20 healthy asymptomatic subjects were enrolled.
Among UDD patients, 20 were assigned to a 2-month course of treatment with Rifaximin 1.2 g/day for 15 days/month and 20 received placebo.
Blood sample and colonic biopsies were obtained from patients and controls.
The samples were collected and analyzed at baseline and at the end of treatment.
Flow cytometry was performed using monoclonal antibodies (CD3, CD4, CD8, CD103, TCR-gamma/delta, CD14, TLR2, and TLR4).
Results.
In UDD, TLR2 and TLR4 expression on immune cell subpopulations from blood and mucosa of the affected colon are altered as compared with controls.
Rifaximin treatment induced significant modifications of altered conditions.
Conclusions.
Our data show the role of TLRs in the development of inflammation in UDD.
TLRs distribution is altered in UDD and these alterations are reversed after antibiotic treatment.
This trial is registered with ClinicalTrials.gov: NCT02068482.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cianci, R.& Frosali, Simona& Cianci, Rossella& Cesaro, Paola& Petruzziello, Lucio& Casciano, Fabio…[et al.]. 2014. Uncomplicated Diverticular Disease: Innate and Adaptive Immunity in Human Gut Mucosa before and after Rifaximin. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1040962
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cianci, R.…[et al.]. Uncomplicated Diverticular Disease: Innate and Adaptive Immunity in Human Gut Mucosa before and after Rifaximin. Journal of Immunology Research No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1040962
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cianci, R.& Frosali, Simona& Cianci, Rossella& Cesaro, Paola& Petruzziello, Lucio& Casciano, Fabio…[et al.]. Uncomplicated Diverticular Disease: Innate and Adaptive Immunity in Human Gut Mucosa before and after Rifaximin. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1040962
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1040962
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر