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Uncomplicated Diverticular Disease: Innate and Adaptive Immunity in Human Gut Mucosa before and after Rifaximin
Joint Authors
Cianci, Rossella
Cianci, R.
Frosali, Simona
Cesaro, Paola
Petruzziello, Lucio
Casciano, Fabio
Costamagna, Guido
Landolfi, R.
Pandolfi, Franco
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-16
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background/Aim.
Uncomplicated diverticular disease (UDD) is a frequent condition in adults.
The pathogenesis of symptoms remains unknown.
Bacteria are able to interact with Toll-like receptors (TLRs) and to induce inflammation through both innate immunity and T-cell recruitment.
We investigated the pattern of TLRs 2 and 4 and the intestinal homing in patients with UDD before and after a course of Rifaximin.
Methods.
Forty consecutive patients with UDD and 20 healthy asymptomatic subjects were enrolled.
Among UDD patients, 20 were assigned to a 2-month course of treatment with Rifaximin 1.2 g/day for 15 days/month and 20 received placebo.
Blood sample and colonic biopsies were obtained from patients and controls.
The samples were collected and analyzed at baseline and at the end of treatment.
Flow cytometry was performed using monoclonal antibodies (CD3, CD4, CD8, CD103, TCR-gamma/delta, CD14, TLR2, and TLR4).
Results.
In UDD, TLR2 and TLR4 expression on immune cell subpopulations from blood and mucosa of the affected colon are altered as compared with controls.
Rifaximin treatment induced significant modifications of altered conditions.
Conclusions.
Our data show the role of TLRs in the development of inflammation in UDD.
TLRs distribution is altered in UDD and these alterations are reversed after antibiotic treatment.
This trial is registered with ClinicalTrials.gov: NCT02068482.
American Psychological Association (APA)
Cianci, R.& Frosali, Simona& Cianci, Rossella& Cesaro, Paola& Petruzziello, Lucio& Casciano, Fabio…[et al.]. 2014. Uncomplicated Diverticular Disease: Innate and Adaptive Immunity in Human Gut Mucosa before and after Rifaximin. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1040962
Modern Language Association (MLA)
Cianci, R.…[et al.]. Uncomplicated Diverticular Disease: Innate and Adaptive Immunity in Human Gut Mucosa before and after Rifaximin. Journal of Immunology Research No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1040962
American Medical Association (AMA)
Cianci, R.& Frosali, Simona& Cianci, Rossella& Cesaro, Paola& Petruzziello, Lucio& Casciano, Fabio…[et al.]. Uncomplicated Diverticular Disease: Innate and Adaptive Immunity in Human Gut Mucosa before and after Rifaximin. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1040962
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040962