Isolated IgA Anti-β2 Glycoprotein I Antibodies in Patients with Clinical Criteria for Antiphospholipid Syndrome
المؤلفون المشاركون
Serrano, Manuel
Martínez-Flores, Jose Angel
Paz-Artal, Estela
Morales, Jose M.
Serrano, Antonio
Ruiz-García, Raquel
Mora, Sergio
Morillas, Luis
Martín-Mola, María Ángeles
المصدر
Journal of Immunology Research
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-23
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Seronegative antiphospholipid syndrome (SNAPS) is an autoimmune disease present in patients with clinical manifestations highly suggestive of Antiphospholipid Syndrome (APS) but with persistently negative consensus antiphospholipid antibodies (a-PL).
IgA anti-β2 Glycoprotein I (aB2-GPI) antibodies are associated with APS.
However, they are not currently considered to be laboratory criteria due to the heterogeneity of published works and the use of poor standardized diagnostic systems.
We have aimed to assess aPL antibodies in a group of patients with clinical manifestations of APS (C-APS) to evaluate the importance of the presence of IgA aB2GPI antibodies in APS and its relation with other aPL antibodies.
Only 14% of patients with C-APS were positive for any consensus antibody, whereas the presence of isolated IgA aB2GPI antibodies was found in 22% of C-APS patients.
In patients with arterial thrombosis IgA aB2GPI, antibodies were the only aPL antibodies present.
Serologic profile in primary APS (PAPS) is different from systemic autoimmune disorders associated APS (SAD-APS).
IgA aB2GPI antibodies are more prevalent in PAPS and IgG aB2GPI antibodies are predominant in SAD-APS.
The analysis of IgA aB2GPI antibodies in patients with clinical manifestations of PAPS might avoid underdiagnosed patients and provide a better diagnosis in patients with SAD-APS.
Laboratory consensus criteria might consider including analysis of IgA aB2GPI for APS diagnosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ruiz-García, Raquel& Serrano, Manuel& Martínez-Flores, Jose Angel& Mora, Sergio& Morillas, Luis& Martín-Mola, María Ángeles…[et al.]. 2014. Isolated IgA Anti-β2 Glycoprotein I Antibodies in Patients with Clinical Criteria for Antiphospholipid Syndrome. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1040965
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ruiz-García, Raquel…[et al.]. Isolated IgA Anti-β2 Glycoprotein I Antibodies in Patients with Clinical Criteria for Antiphospholipid Syndrome. Journal of Immunology Research No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1040965
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ruiz-García, Raquel& Serrano, Manuel& Martínez-Flores, Jose Angel& Mora, Sergio& Morillas, Luis& Martín-Mola, María Ángeles…[et al.]. Isolated IgA Anti-β2 Glycoprotein I Antibodies in Patients with Clinical Criteria for Antiphospholipid Syndrome. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1040965
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1040965
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر