Isolated IgA Anti-β2 Glycoprotein I Antibodies in Patients with Clinical Criteria for Antiphospholipid Syndrome
Joint Authors
Serrano, Manuel
Martínez-Flores, Jose Angel
Paz-Artal, Estela
Morales, Jose M.
Serrano, Antonio
Ruiz-García, Raquel
Mora, Sergio
Morillas, Luis
Martín-Mola, María Ángeles
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Seronegative antiphospholipid syndrome (SNAPS) is an autoimmune disease present in patients with clinical manifestations highly suggestive of Antiphospholipid Syndrome (APS) but with persistently negative consensus antiphospholipid antibodies (a-PL).
IgA anti-β2 Glycoprotein I (aB2-GPI) antibodies are associated with APS.
However, they are not currently considered to be laboratory criteria due to the heterogeneity of published works and the use of poor standardized diagnostic systems.
We have aimed to assess aPL antibodies in a group of patients with clinical manifestations of APS (C-APS) to evaluate the importance of the presence of IgA aB2GPI antibodies in APS and its relation with other aPL antibodies.
Only 14% of patients with C-APS were positive for any consensus antibody, whereas the presence of isolated IgA aB2GPI antibodies was found in 22% of C-APS patients.
In patients with arterial thrombosis IgA aB2GPI, antibodies were the only aPL antibodies present.
Serologic profile in primary APS (PAPS) is different from systemic autoimmune disorders associated APS (SAD-APS).
IgA aB2GPI antibodies are more prevalent in PAPS and IgG aB2GPI antibodies are predominant in SAD-APS.
The analysis of IgA aB2GPI antibodies in patients with clinical manifestations of PAPS might avoid underdiagnosed patients and provide a better diagnosis in patients with SAD-APS.
Laboratory consensus criteria might consider including analysis of IgA aB2GPI for APS diagnosis.
American Psychological Association (APA)
Ruiz-García, Raquel& Serrano, Manuel& Martínez-Flores, Jose Angel& Mora, Sergio& Morillas, Luis& Martín-Mola, María Ángeles…[et al.]. 2014. Isolated IgA Anti-β2 Glycoprotein I Antibodies in Patients with Clinical Criteria for Antiphospholipid Syndrome. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1040965
Modern Language Association (MLA)
Ruiz-García, Raquel…[et al.]. Isolated IgA Anti-β2 Glycoprotein I Antibodies in Patients with Clinical Criteria for Antiphospholipid Syndrome. Journal of Immunology Research No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1040965
American Medical Association (AMA)
Ruiz-García, Raquel& Serrano, Manuel& Martínez-Flores, Jose Angel& Mora, Sergio& Morillas, Luis& Martín-Mola, María Ángeles…[et al.]. Isolated IgA Anti-β2 Glycoprotein I Antibodies in Patients with Clinical Criteria for Antiphospholipid Syndrome. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1040965
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040965